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Gene Review

cyaC  -  cyclolysin-activating lysine-acyltransferase

Bordetella pertussis Tohama I

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Disease relevance of cyaC


High impact information on cyaC

  • In that AC toxin from BPDE386 is able to function normally when injected artificially to an intracellular site, we conclude that the disruption of cyaC produces a defect in insertion and transmembrane delivery of the catalytic domain [2].
  • AC-Hly possesses both adenylate cyclase toxic and hemolytic activities that depend on a posttranslational modification mediated by the product of the cyaC gene [3].
  • The role of the cyaC gene product in the acylation reaction has not been determined [4].
  • Activation to the mature cell-invasive toxin involves palmitoylation of lysine 983 and is dependent on co-expression of cyaC [4].
  • The cyaB, D and E gene products are necessary for CyaA transport, and the cyaC gene product is required to activate CyaA [5].

Chemical compound and disease context of cyaC


Other interactions of cyaC

  • Bordetella pertussis produces a cell-invasive adenylate cyclase toxin which is synthesised from the cyaA gene as an inactive protoxin that is post-translationally activated by the product of the cyaC gene [1].


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