Disease relevance of fim2

• Cloning of a novel pilin-like gene from Bordetella pertussis: homology to the fim2 gene [1].
• By following CAT activity in Bordetella bronchiseptica vir+ and vir- strains we established that the fimX promoter, like those for fim2 and fim3, is active, although at a low level, and vir-regulated [2].

High impact information on fim2

• Nucleotide sequence of the fim3 gene from Bordetella pertussis and homology to fim2 and fimX gene products [3].
• Serotype 2 fimbriae, composed of the fim2 subunit which is 60% homologous with fim3, have essentially the same quaternary structure [4].
• A DNA fragment from Bordetella pertussis, encoding the fim2 fimbrial subunit gene with adjacent sequences, was used as a probe for the detection of homologous sequences in chromosomal DNA of Bordetella avium [5].

Biological context of fim2

• In this communication we present the cloning and nucleotide sequence of the fimX gene and its homology to the fim2 gene [1].
• Comparison of the putative promoter regions of the fim2 and fim3 genes revealed a conserved region containing a stretch of approximately 13 C's. This region may be involved in fimbrial phase variation [6].

References