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Gene Review

fim2  -  serotype 2 fimbrial subunit

Bordetella pertussis Tohama I

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Disease relevance of fim2

  • Cloning of a novel pilin-like gene from Bordetella pertussis: homology to the fim2 gene [1].
  • By following CAT activity in Bordetella bronchiseptica vir+ and vir- strains we established that the fimX promoter, like those for fim2 and fim3, is active, although at a low level, and vir-regulated [2].

High impact information on fim2


Biological context of fim2

  • In this communication we present the cloning and nucleotide sequence of the fimX gene and its homology to the fim2 gene [1].
  • Comparison of the putative promoter regions of the fim2 and fim3 genes revealed a conserved region containing a stretch of approximately 13 C's. This region may be involved in fimbrial phase variation [6].


  1. Cloning of a novel pilin-like gene from Bordetella pertussis: homology to the fim2 gene. Pedroni, P., Riboli, B., de Ferra, F., Grandi, G., Toma, S., Aricò, B., Rappuoli, R. Mol. Microbiol. (1988) [Pubmed]
  2. Expression of Bordetella pertussis fimbrial (fim) genes in Bordetella bronchiseptica: fimX is expressed at a low level and vir-regulated. Riboli, B., Pedroni, P., Cuzzoni, A., Grandi, G., de Ferra, F. Microb. Pathog. (1991) [Pubmed]
  3. Nucleotide sequence of the fim3 gene from Bordetella pertussis and homology to fim2 and fimX gene products. Cuzzoni, A., Pedroni, P., Riboli, B., Grandi, G., de Ferra, F. Nucleic Acids Res. (1990) [Pubmed]
  4. Three-dimensional structure of Bordetella pertussis fimbriae. Heck, D.V., Trus, B.L., Steven, A.C. J. Struct. Biol. (1996) [Pubmed]
  5. Identification of Bordetella avium using the polymerase chain reaction. Savelkoul, P.H., de Groot, L.E., Boersma, C., Livey, I., Duggleby, C.J., van der Zeijst, B.A., Gaastra, W. Microb. Pathog. (1993) [Pubmed]
  6. Structure of the Bordetella pertussis gene coding for the serotype 3 fimbrial subunit. Mooi, F.R., ter Avest, A., van der Heide, H.G. FEMS Microbiol. Lett. (1990) [Pubmed]
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