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Gene Review:

alcR - transcriptional regulator

Bordetella pertussis Tohama I

Brickman, T.J. et al., Beaumont, F.C. et al., Brickman, T.J. et al., Pradel, E. et al.

Brickman, Armstrong,

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Disease relevance of alcR

Phenotypic analysis using heterologous host systems localized putative Bordetella pertussis ferric alcaligin transport genes and Fur-binding sequences to a 3.8-kb genetic region downstream from the alcR regulator gene [1].

High impact information on alcR

Transcriptional analyses using plasmid-borne alcR genes of B. pertussis UT25 and B. bronchiseptica B013N to complement the alcR defect of B. bronchiseptica strain BRM13 (Delta alcR1 alcA::mini-Tn5 lacZ1) revealed interspecies differences in AlcR inducer requirements for activation of alcABCDER operon transcription [2].
Additional sequence determination showed that alcR is located about 2 kb downstream from the alcABC operon and is transcribed in the same orientation [3].
Nucleotide sequencing of this complementing 1.6-kb region identified an open reading frame predicted to encode a protein with strong similarity to members of the AraC family of transcriptional regulators, for which we propose the gene designation alcR [4].

References

Essential role of the iron-regulated outer membrane receptor FauA in alcaligin siderophore-mediated iron uptake in Bordetella species. Brickman, T.J., Armstrong, S.K. J. Bacteriol. (1999) [Pubmed]
Bordetella interspecies allelic variation in AlcR inducer requirements: identification of a critical determinant of AlcR inducer responsiveness and construction of an alcR(Con) mutant allele. Brickman, T.J., Armstrong, S.K. J. Bacteriol. (2002) [Pubmed]
Identification of AlcR, an AraC-type regulator of alcaligin siderophore synthesis in Bordetella bronchiseptica and Bordetella pertussis. Pradel, E., Guiso, N., Locht, C. J. Bacteriol. (1998) [Pubmed]
Identification and characterization of alcR, a gene encoding an AraC-like regulator of alcaligin siderophore biosynthesis and transport in Bordetella pertussis and Bordetella bronchiseptica. Beaumont, F.C., Kang, H.Y., Brickman, T.J., Armstrong, S.K. J. Bacteriol. (1998) [Pubmed]

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