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Gene Review:

AK2P1 - adenylate kinase 2 pseudogene 1

Homo sapiens

Synonyms: AK2B

Lee, Y. et al., Lee, Y. et al., Nakazawa, A. et al.

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Disease relevance of AK2B

Each of the recombinant proteins, AK2A and AK2B, was expressed in Escherichia coli cells, and the purified recombinant proteins were enzymatically active [1].

High impact information on AK2B

The nucleotide sequence of the ORF of the AK2B pseudogene predicted a truncated form of the AK2B mutant suggesting that the processed pseudogene is nonfunctional [2].
A chromosomal DNA sequence harboring a processed AK2B pseudogene was isolated from a human genomic library [2].
It was a variant of the AK2B gene sequence including several point mutations, deletions, and insertions [2].
A repetitive sequence, AAAAGAGAG, found in the 5' and 3' flanking regions of the pseudogene and the poly(A) tract in the 3' end junction suggest that a mRNA of AK2B may have been converted to the processed pseudogene by retrotransposition events [2].
The other type (AK2B) encoded the same sequence as AK2 except for the COOH terminus [3].

References

Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. Lee, Y., Kim, J.W., Lee, S.M., Kim, H.J., Lee, K.S., Park, C., Choe, I.S. J. Biochem. (1998) [Pubmed]
Cloning of the genomic sequence encoding a processed adenylate kinase 2 pseudogene. Lee, Y., Hong, M., Kim, Y.J., Kim, J.W., Kim, C.H., Lee, K.S., Chang, S.Y., Lim, J.S., Choe, I.S. Biochem. Mol. Biol. Int. (1999) [Pubmed]
Gene structures of three vertebrate adenylate kinase isozymes. Nakazawa, A., Yamada, M., Tanaka, H., Shahjahan, M., Tanabe, T. Prog. Clin. Biol. Res. (1990) [Pubmed]

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