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Gene Review:

SNORD33 - small nucleolar RNA, C/D box 33

Homo sapiens

Synonyms: RNU33, U33

Auffinger, P. et al., Li, S.J. et al., Crain, P.F. et al., Ashraf, S.S. et al.

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High impact information on SNORD33

This analysis revealed extensive mitochondria-specific posttranscriptional modifications, including the first example of thiolation of U33, the "universally unmodified" uridine [1].
Here, on the basis of phylogenetic, structural, and molecular dynamics data, we discuss a conserved interaction established between the ribose of the U33 and the base at position 35, either a purine or a pyrimidine [2].
This interaction involves the hydrogen bonding donor or acceptor potential of the hydroxyl group of U33 and has to be integrated in an extended definition of the anticodon hairpin [2].
To better understand these interactions, U33-substituted yeast tRNA(Phe) anticodon stem and loop domains (ASLs) were used as probes of anticodon orientation on the ribosome [3].
Two base pairs, G41 X C34 and A42 X U33 in the hairpin loop, could account for the lack of binding between the conserved GAAC segment of 5S RNA and the conserved Watson-Crick-complementary GT psi C segment of tRNAs [4].

References

Modification of the universally unmodified uridine-33 in a mitochondria-imported edited tRNA and the role of the anticodon arm structure on editing efficiency. Crain, P.F., Alfonzo, J.D., Rozenski, J., Kapushoc, S.T., McCloskey, J.A., Simpson, L. RNA (2002) [Pubmed]
An extended structural signature for the tRNA anticodon loop. Auffinger, P., Westhof, E. RNA (2001) [Pubmed]
Orientation of the tRNA anticodon in the ribosomal P-site: quantitative footprinting with U33-modified, anticodon stem and loop domains. Ashraf, S.S., Guenther, R., Agris, P.F. RNA (1999) [Pubmed]
500-MHz proton homonuclear Overhauser evidence for additional base pair in the common arm of eukaryotic ribosomal 5S RNA: wheat germ. Li, S.J., Wu, J.J., Marshall, A.G. Biochemistry (1987) [Pubmed]

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