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Chemical Compound Review

D-ribose     (2R,3R,4R)-2,3,4,5- tetrahydroxypentanal

Synonyms: Ribose, D-, AG-C-85362, AG-F-70659, CHEBI:47014, ANW-31099, ...
 
 
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Disease relevance of D-ribose

 

High impact information on D-ribose

  • PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation [6].
  • This discovery implies that most snoRNAs function in targeting nucleotide modification in rRNA: ribose methylation for the box C/D snoRNAs and psi formation for the ACA snoRNAs [7].
  • Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs [8].
  • Translocation of polypeptides is a late event relative to extent of elongation, occurring only after maltose-binding protein has reached molecular weight 33,000 (80% of its entire length) and after ribose-binding protein has been fully elongated (molecular weight 29,000) [9].
  • These trg mutants are indistinguishable from their parent in tactic response to other attractants, swimming pattern, growth rates, and transport of ribose and galactose [1].
 

Chemical compound and disease context of D-ribose

 

Biological context of D-ribose

  • Sos does not impede the binding sites for the base and the ribose of GTP or GDP, so the Ras-Sos complex adopts a structure that allows nucleotide release and rebinding [15].
  • One candidate pathway is DNA damage leading to activation of the nuclear enzyme, poly(ADP-ribose) polymerase (PARP), which catalyzes attachment of ADP ribose units from NAD to nuclear proteins following DNA damage [16].
  • Surprisingly, this partition of aaRS in two classes is found to be strongly correlated on the functional level with the acylation occurring either on the 2' OH (class I) or 3' OH (class II) of the ribose of the last nucleotide of tRNA [17].
  • Late after induction, translocation of beta-lactamase was impaired; this may be an indirect effect of heat shock, however, because translocation of ribose binding protein or of the porin, OmpA, was unaffected [18].
  • The aminoacylation of synthetic tDNAs demonstrates that the ribose backbone of a tRNA is not absolutely required for tRNA aminoacylation [19].
 

Anatomical context of D-ribose

 

Associations of D-ribose with other chemical compounds

 

Gene context of D-ribose

  • The C and D box-containing snoRNAs are associated with fibrillarin, and most of them function as guide RNAs in site-specific ribose methylation of rRNAs [29].
  • MKP-1 was also found to inhibit other biochemical events associated with apoptosis, including activation of caspase-3 and the proteolytic cleavage of the caspase-3 substrate, poly(ADP ribose) polymerase [30].
  • It includes the 3' terminus of rbsB (the gene for ribose-binding protein) and the entire rbsK gene, encoding ribokinase [31].
  • Further analyses of the mutants revealed that the rbsK (ribokinase) and rbsD (function unknown) genes are involved in the ribose transport through PtsG, indicating that the phosphorylation of ribose is not mediated by PtsG and that some unknown metabolic function mediated by RbsD is required [32].
  • Transaldolase regulates redox-dependent apoptosis through controlling NADPH and ribose 5-phosphate production via the pentose phosphate pathway [33].
 

Analytical, diagnostic and therapeutic context of D-ribose

References

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