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Gene Review:

RNU4-4P - RNA, U4 small nuclear 4, pseudogene

Homo sapiens

Synonyms: RNU4P4, U4, U4/5

Zerby, D.B. et al., Bae, E. et al., Jacob, M. et al., Kiss, T. et al.

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High impact information on RNU4P4

The requirements for the formation of pseudouridine (psi) in U4 and U6 RNAs, cofactors in the splicing of pre-messenger RNA, were investigated in vitro using HeLa nuclear (NE) and cytoplasmic (S100) extracts [1].
Metabolism of pre-messenger RNA splicing cofactors: modification of U6 RNA is dependent on its interaction with U4 RNA [1].
A model is proposed for the base pairing interaction of broad bean U4 RNA with broad bean U6 RNA [2].
U1, U2, U4 and U5 RNAs are capped (with trimethylguanosine) and the consensus sequence for their 6 first nucleotides is A-(Py)5p [3].

Anatomical context of RNU4P4

The essential Saccharomyces cerevisiae pre-messenger RNA splicing protein 24 (Prp24) has four RNA recognition motifs (RRMs) and facilitates U6 RNA base-pairing with U4 RNA during spliceosome assembly [4].

References

Metabolism of pre-messenger RNA splicing cofactors: modification of U6 RNA is dependent on its interaction with U4 RNA. Zerby, D.B., Patton, J.R. Nucleic Acids Res. (1996) [Pubmed]
Plant small nuclear RNAs. V. U4 RNA is present in broad bean plants in the form of sequence variants and is base-paired with U6 RNA. Kiss, T., Jakab, G., Antal, M., Pálfi, Z., Hegyi, H., Kis, M., Solymosy, F. Nucleic Acids Res. (1988) [Pubmed]
A family of small nucleoplasmic RNAs with common structural features. Jacob, M., Lazar, E., Haendler, B., Gallinaro, H., Krol, A., Branlant, C. Biol. Cell (1984) [Pubmed]
Structure and interactions of the first three RNA recognition motifs of splicing factor prp24. Bae, E., Reiter, N.J., Bingman, C.A., Kwan, S.S., Lee, D., Phillips, G.N., Butcher, S.E., Brow, D.A. J. Mol. Biol. (2007) [Pubmed]

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