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Gene Review

Gpx6  -  glutathione peroxidase 6

Mus musculus

Synonyms: 1700020G18Rik, GPx-6, GSHPx-6, Glutathione peroxidase 6, Ry2d1, ...
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Disease relevance of Gpx6


Psychiatry related information on Gpx6

  • Major new insights are: Olfaction is accomplished in vertebrates by a very large number of receptors; olfactory sensory neurons express a small subset of the OR repertoire; in rat and mouse, axons of neurons expressing the same OR converge onto defined glomeruli in the olfactory bulb [5].
  • Behavioral phenotyping indicated that GAL-tgs displayed normal general health and sensory and motor abilities; however, GAL-tg mice showed selective performance deficits on the Morris spatial navigational task and the social transmission of food preference olfactory memory test [6].
  • Critical period for sensory experience-dependent survival of newly generated granule cells in the adult mouse olfactory bulb [7].
  • By using an operant conditioning paradigm, we show that CNGA4-null mice are profoundly impaired in the detection and discrimination of olfactory stimuli in the presence of an adapting background odor [8].
  • Recent observations have implicated the vomeronasal (accessory olfactory) system in the chemosensory control of rodent social behaviors [9].

High impact information on Gpx6


Chemical compound and disease context of Gpx6


Biological context of Gpx6


Anatomical context of Gpx6


Associations of Gpx6 with chemical compounds

  • To date the molecular signalling involved in this trans-synaptic induction has not yet been characterized; I have therefore studied the expression of dopaminergic properties (presence of TH and dopamine uptake) in dissociated cell cultures from embryonic mouse olfactory bulb [22].
  • Using a combination of LHRH immunocytochemistry and tritiated thymidine autoradiography in fetal mice, we show that LHRH neurons originate in the medial olfactory placode of the developing nose, migrate across the nasal septum and enter the forebrain with the nervus terminalis, arching into the septal-preoptic area and hypothalamus [29].
  • The formation of this memory is mediated by the accessory olfactory system, in which an increase in norepinephrine after mating reduces inhibitory transmission of gamma-aminobutyric acid from the granule cells to the mitral cells [30].
  • Induction of an olfactory memory by the activation of a metabotropic glutamate receptor [30].
  • For two unrelated ligands, androstenone and isovaleric acid, induction of olfactory sensitivity was odorant-specific and occurred only in inbred strains that initially had low sensitivity to the exposure odorant [31].

Physical interactions of Gpx6

  • In vivo proliferation of olfactory neuronal lineage cells thus involves functional binding of cyclin D1 with cdk2 and cdk4, with differential activation mechanisms for cdk2 and cdk4 [32].
  • Although virtually nothing is known about sensory transduction in the mammalian VNO, recent findings have raised the possibility that it proceeds via a G-protein-coupled mechanism and involves a cyclic nucleotide-gated ion channel as in the nasal olfactory epithelium [33].
  • The pattern of VSV immunoreactivity supports the idea that following infection of the olfactory bulb glomeruli, VSV spreads via both ventricular surfaces and retrograde transport within axons of neuromodulatory transmitter systems innervating the olfactory bulb [34].

Co-localisations of Gpx6

  • Alpha-internexin and peripherin were first found to be co-localized in the olfactory neuroepithelium during early development [35].
  • The CYP2A5 mRNA and the corresponding protein co-localized at most sites and were predominantly detected in the olfactory region, with an expression in sustentacular cells, Bowman's gland, and duct cells [36].

Regulatory relationships of Gpx6


Other interactions of Gpx6


Analytical, diagnostic and therapeutic context of Gpx6

  • We have employed gene targeting to visualize the pattern of projections of axons from vomeronasal sensory neurons in the accessory olfactory bulb [24].
  • Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula [47].
  • Transplantation studies have been used to show that tangential migration of olfactory bulb interneuron precursors is retarded in NCAM-mutant mice, and that this defect reflects loss of NCAM polysialic acid (PSA) [48].
  • Interestingly, electroolfactogram (EOG) responses stimulated by either cAMP- or inositol 1,4,5-triphosphate- (IP3-) inducing odorants were completely ablated in AC3 mutants, despite the presence of AC2 and AC4 in olfactory cilia [49].
  • In a paper in this issue of Neuron, Lin et al. combined gas chromatography and intrinsic signal imaging to examine the responses of individual olfactory bulb glomeruli in the mouse to natural odors and their component parts [50].


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