The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

TCL6  -  T-cell leukemia/lymphoma 6 (non-protein...

Homo sapiens

Synonyms: TCL6e1, TNG1, TNG2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TCL6

  • In the course of characterizing the TML1 gene, we further identified a third novel gene, which we named TCL6 (T-cell leukemia/lymphoma 6), from a region 7 kb upstream of the TML1 locus [1].
  • TNG1 and TNG2 also are activated in T cell leukemias with rearrangements at 14q32 [2].
 

High impact information on TCL6

  • We isolated and characterized four genes at this locus, TCL1 and TCL1b (T-cell leukemia/lymphoma 1 and 1b), and TNG1 and TNG2 (TCL neighboring genes 1 and 2) all of which are overexpressed following rearrangements involving 14q32 [3].
  • Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia [1].
  • The TCL6 gene expressed at least 11 isoforms through very complex alternative-splicing, including splicing with the TML1 gene [1].

References

  1. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. Saitou, M., Sugimoto, J., Hatakeyama, T., Russo, G., Isobe, M. Oncogene (2000) [Pubmed]
  2. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. Hallas, C., Pekarsky, Y., Itoyama, T., Varnum, J., Bichi, R., Rothstein, J.L., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. The role of TCL1 in human T-cell leukemia. Pekarsky, Y., Hallas, C., Croce, C.M. Oncogene (2001) [Pubmed]
 
WikiGenes - Universities