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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

TCL6  -  T-cell leukemia/lymphoma 6 (non-protein...

Homo sapiens

Synonyms: TCL6e1, TNG1, TNG2
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Disease relevance of TCL6

  • In the course of characterizing the TML1 gene, we further identified a third novel gene, which we named TCL6 (T-cell leukemia/lymphoma 6), from a region 7 kb upstream of the TML1 locus [1].
  • TNG1 and TNG2 also are activated in T cell leukemias with rearrangements at 14q32 [2].

High impact information on TCL6

  • We isolated and characterized four genes at this locus, TCL1 and TCL1b (T-cell leukemia/lymphoma 1 and 1b), and TNG1 and TNG2 (TCL neighboring genes 1 and 2) all of which are overexpressed following rearrangements involving 14q32 [3].
  • Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia [1].
  • The TCL6 gene expressed at least 11 isoforms through very complex alternative-splicing, including splicing with the TML1 gene [1].


  1. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. Saitou, M., Sugimoto, J., Hatakeyama, T., Russo, G., Isobe, M. Oncogene (2000) [Pubmed]
  2. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. Hallas, C., Pekarsky, Y., Itoyama, T., Varnum, J., Bichi, R., Rothstein, J.L., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. The role of TCL1 in human T-cell leukemia. Pekarsky, Y., Hallas, C., Croce, C.M. Oncogene (2001) [Pubmed]
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