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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SND1  -  staphylococcal nuclease and tudor domain...

Homo sapiens

Synonyms: 100 kDa coactivator, EBNA2 coactivator p100, Staphylococcal nuclease domain-containing protein 1, TDRD11, Tudor domain-containing protein 11, ...
 
 
 

Disease relevance of SND1

  • Immunohistochemical analysis using chemically induced colonic lesions developed in rats revealed overexpression of Snd1 not only in colon cancers but also in aberrant crypt foci, putative precancerous lesions of the colon [1].
 

High impact information on SND1

  • SND1 is involved in RISC complex and ii interacts with AEG-1 and plays pivotal role in Hepatocellular carcinoma [2],  .
  • Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization [3]. SND1 also plays very important role in breast cancer metastasis[3][  

 

 

 

 

References

  1. SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis. Tsuchiya, N., Ochiai, M., Nakashima, K., Ubagai, T., Sugimura, T., Nakagama, H. Cancer Res. (2007) [Pubmed]
  2. Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology. Yoo, B.K., Emdad, L., Lee, S.G., Su, Z.Z., Santhekadur, P., Chen, D., Gredler, R., Fisher, P.B., Sarkar, D. Pharmacol. Ther. (2011) [Pubmed]
  3. Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization. Liénard, P., Rivière, M., Van Vooren, P., Szpirer, C., Szpirer, J. Cytogenet. Cell Genet. (2000) [Pubmed]
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