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Gene Review

TAF5L  -  TAF5-like RNA polymerase II, p300/CBP...

Homo sapiens

Synonyms: PAF65-beta, PAF65B, PCAF-associated factor 65 beta, TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
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High impact information on TAF5L

  • The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients [1].
  • Our results suggest that the TAF5L gene, encoding TAF5L-like RNA polymerase II p300/CBP associated factor (PCAF)-associated factor, could represent the susceptibility gene for T1D on chromosome 1q42 in Russian affected patients [1].
  • Together with the A/C744 TAF5L SNP, these markers share common T(-25)/A744/T1362 and C(-25)/C744/T1362 haplotypes associated with higher and lower risk of diabetes (Odds Ratio = 2.15 and 0.62, respectively) [1].


  1. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. Chistiakov, D.A., Chernisheva, A., Savost'anov, K.V., Turakulov, R.I., Kuraeva, T.L., Dedov, I.I., Nosikov, V.V. Autoimmunity (2005) [Pubmed]
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