Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

tnpA - hypothetical protein

Escherichia coli

Pasquali, F. et al., Wallace, L.J. et al., Gierl, A. et al.

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Disease relevance of tnpA

TnpA protein, the function encoded by the most abundant transcript of En-1 was expressed in Escherichia coli [1].

High impact information on tnpA

TnpA product encoded by the transposable element En-1 of Zea mays is a DNA binding protein [1].
RESULTS: Plasmid pFPTB1 contains a complete Tn3-like transposon of 4950 bp consisting of the left terminal repeat, Tn3-related tnpR and tnpA genes for transposition functions, a novel gene for ampicillin resistance bla(TEM-135), and the right terminal repeat [2].

Other interactions of tnpA

The requirement for wild type tnpR gene product for the establishment of transposition immunity was confirmed by the use of a derivative of transposon Tn3 in which both the tnpA and the tnpR genes are partly deleted [3].

References

TnpA product encoded by the transposable element En-1 of Zea mays is a DNA binding protein. Gierl, A., Lütticke, S., Saedler, H. EMBO J. (1988) [Pubmed]
Physical linkage of Tn3 and part of Tn1721 in a tetracycline and ampicillin resistance plasmid from Salmonella Typhimurium. Pasquali, F., Kehrenberg, C., Manfreda, G., Schwarz, S. J. Antimicrob. Chemother. (2005) [Pubmed]
The tnpR gene product of TnA is required for transposition immunity. Wallace, L.J., Ward, J.M., Richmond, M.H. Mol. Gen. Genet. (1981) [Pubmed]

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