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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GLC1B  -  glaucoma 1, open angle, B (adult-onset)

Homo sapiens

 
 
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Disease relevance of GLC1B

 

High impact information on GLC1B

  • Herein, we present a new locus (GLC1B) for one form of GLC1 on chromosome 2cen-q13 with a clinical presentation of low to moderate intraocular pressure, onset in late 40s, and a good response to medical treatment [1].
  • The 9 cM haplotype of interest overlaps the original GLC1B region [2].
 

Biological context of GLC1B

  • These results provide supportive evidence for the GLC1B locus on chromosome 2cen-q13 and verify the existence of POAG susceptibility gene in this region, increasing the likelihood of gene identification [2].

References

  1. Localization of a locus (GLC1B) for adult-onset primary open angle glaucoma to the 2cen-q13 region. Stoilova, D., Child, A., Trifan, O.C., Crick, R.P., Coakes, R.L., Sarfarazi, M. Genomics (1996) [Pubmed]
  2. Confirmation of the adult-onset primary open angle glaucoma locus GLC1B at 2cen-q13 in an Australian family. Charlesworth, J.C., Stankovich, J.M., Mackey, D.A., Craig, J.E., Haybittel, M., Westmore, R.N., Sale, M.M. Ophthalmologica (2006) [Pubmed]
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