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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Glaucoma, Open-Angle

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Disease relevance of Glaucoma, Open-Angle


High impact information on Glaucoma, Open-Angle


Chemical compound and disease context of Glaucoma, Open-Angle


Biological context of Glaucoma, Open-Angle


Anatomical context of Glaucoma, Open-Angle


Gene context of Glaucoma, Open-Angle

  • MYOC mutations included cases of juvenile glaucoma with or without pigmentary glaucoma and mixed-mechanism glaucoma [9].
  • Herein, we report mapping of a new adult-onset primary open-angle glaucoma (POAG) locus on 5q22.1 (GLC1G) and identification of its defective gene [26].
  • Due to opticin's protein profile in the eye, we have also screened OPTC for mutations in individuals with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) or AMD [27].
  • PURPOSE: It has been shown that mutations in the optineurin (OPTN) gene are involved in the etiology of adult-onset primary open-angle glaucoma (POAG) [28].
  • These results indicate that unlike NTG, the OPA1 genotype IVS8+4 C/T,+32T/C is not significantly associated with high-tension primary open angle glaucoma, and suggest genetic heterogeneity between the conditions [29].

Analytical, diagnostic and therapeutic context of Glaucoma, Open-Angle


  1. Genetic heterogeneity of primary open angle glaucoma and ocular hypertension: linkage to GLC1A associated with an increased risk of severe glaucomatous optic neuropathy. Brézin, A.P., Béchetoille, A., Hamard, P., Valtot, F., Berkani, M., Belmouden, A., Adam, M.F., Dupont de Dinechin, S., Bach, J.F., Garchon, H.J. J. Med. Genet. (1997) [Pubmed]
  2. Concentration of latanoprost ophthalmic solution after 4 to 6 weeks' use in an eye clinic setting. Varma, R., Winarko, J., Kiat-Winarko, T., Winarko, B. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  3. Female reproductive factors and eye disease in a rural South Indian population: the Aravind Comprehensive Eye Survey. Nirmalan, P.K., Katz, J., Robin, A.L., Ramakrishnan, R., Krishnadas, R., Thulasiraj, R.D., Tielsch, J.M. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  4. S (blue) cone pathway vulnerability in retinitis pigmentosa, diabetes and glaucoma. Greenstein, V.C., Hood, D.C., Ritch, R., Steinberger, D., Carr, R.E. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  5. Aqueous misdirection after glaucoma drainage device implantation. Greenfield, D.S., Tello, C., Budenz, D.L., Liebmann, J.M., Ritch, R. Ophthalmology (1999) [Pubmed]
  6. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A). Alward, W.L., Fingert, J.H., Coote, M.A., Johnson, A.T., Lerner, S.F., Junqua, D., Durcan, F.J., McCartney, P.J., Mackey, D.A., Sheffield, V.C., Stone, E.M. N. Engl. J. Med. (1998) [Pubmed]
  7. Juvenile glaucoma, race, and refraction. Lotufo, D., Ritch, R., Szmyd, L., Burris, J.E. JAMA (1989) [Pubmed]
  8. Timolol in the treatment of open angle glaucoma. Kosman, M.E. JAMA (1979) [Pubmed]
  9. Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. Vincent, A.L., Billingsley, G., Buys, Y., Levin, A.V., Priston, M., Trope, G., Williams-Lyn, D., Héon, E. Am. J. Hum. Genet. (2002) [Pubmed]
  10. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Copin, B., Brézin, A.P., Valtot, F., Dascotte, J.C., Béchetoille, A., Garchon, H.J. Am. J. Hum. Genet. (2002) [Pubmed]
  11. Defects in cortisol-metabolizing enzymes in primary open-angle glaucoma. Weinstein, B.I., Munnangi, P., Gordon, G.G., Southren, A.L. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  12. Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes. Clark, A.F., Wilson, K., de Kater, A.W., Allingham, R.R., McCartney, M.D. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  13. Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Gonzalez, J.P., Clissold, S.P. Drugs (1987) [Pubmed]
  14. Ocular metipranolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in glaucoma and ocular hypertension. Battershill, P.E., Sorkin, E.M. Drugs (1988) [Pubmed]
  15. Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Gherghel, D., Griffiths, H.R., Hilton, E.J., Cunliffe, I.A., Hosking, S.L. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  16. Optimedin: a novel olfactomedin-related protein that interacts with myocilin. Torrado, M., Trivedi, R., Zinovieva, R., Karavanova, I., Tomarev, S.I. Hum. Mol. Genet. (2002) [Pubmed]
  17. Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Zillig, M., Wurm, A., Grehn, F.J., Russell, P., Tamm, E.R. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  18. Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population. Hashizume, K., Mashima, Y., Fumayama, T., Ohtake, Y., Kimura, I., Yoshida, K., Ishikawa, K., Yasuda, N., Fujimaki, T., Asaoka, R., Koga, T., Kanamoto, T., Fukuchi, T., Miyaki, K. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  19. Increased plasma noncortisol glucocorticoid activity in open-angle glaucoma. McCarty, G.R., Schwartz, B. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  20. Characterization of melanosomes in murine Hermansky-Pudlak syndrome: mechanisms of hypopigmentation. Nguyen, T., Wei, M.L. J. Invest. Dermatol. (2004) [Pubmed]
  21. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. Zhou, X., Li, F., Kong, L., Tomita, H., Li, C., Cao, W. J. Biol. Chem. (2005) [Pubmed]
  22. Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis. Goldwich, A., Baulmann, D.C., Ohlmann, A., Flügel-Koch, C., Schöcklmann, H., Tamm, E.R. Kidney Int. (2005) [Pubmed]
  23. Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. Fingert, J.H., Clark, A.F., Craig, J.E., Alward, W.L., Snibson, G.R., McLaughlin, M., Tuttle, L., Mackey, D.A., Sheffield, V.C., Stone, E.M. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  24. A latent collagenase in human aqueous humor. Vadillo-Ortega, F., González-Avila, G., Chevez, P., Abraham, C.R., Montaño, M., Selman-Lama, M. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  25. Ultrastructural immunocytochemical analysis of elastin in the human lamina cribrosa. Changes in elastic fibers in primary open-angle glaucoma. Hernandez, M.R. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  26. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Monemi, S., Spaeth, G., DaSilva, A., Popinchalk, S., Ilitchev, E., Liebmann, J., Ritch, R., Héon, E., Crick, R.P., Child, A., Sarfarazi, M. Hum. Mol. Genet. (2005) [Pubmed]
  27. Protein localization in the human eye and genetic screen of opticin. Friedman, J.S., Faucher, M., Hiscott, P., Biron, V.L., Malenfant, M., Turcotte, P., Raymond, V., Walter, M.A. Hum. Mol. Genet. (2002) [Pubmed]
  28. Molecular cloning and expression profiling of optineurin in the rhesus monkey. Rezaie, T., Waitzman, D.M., Seeman, J.L., Kaufman, P.L., Sarfarazi, M. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  29. Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. Aung, T., Ocaka, L., Ebenezer, N.D., Morris, A.G., Brice, G., Child, A.H., Hitchings, R.A., Lehmann, O.J., Bhattacharya, S.S. Hum. Genet. (2002) [Pubmed]
  30. Restoring sensitivity to timolol after long-term drift in primary open-angle glaucoma. Gandolfi, S.A. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  31. A comparison of antinuclear antibodies and DNA-binding antibodies in chronic open-angle glaucoma. Felberg, N.T., Leon, S.A., Gasparini, J., Spaeth, G.L. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  32. Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage. Pang, I.H., Johnson, E.C., Jia, L., Cepurna, W.O., Shepard, A.R., Hellberg, M.R., Clark, A.F., Morrison, J.C. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  33. 5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study. Goldenfeld, M., Krupin, T., Ruderman, J.M., Wong, P.C., Rosenberg, L.F., Ritch, R., Liebmann, J.M., Gieser, D.K. Ophthalmology (1994) [Pubmed]
  34. A 12-month, randomized, double-masked study comparing latanoprost with timolol in pigmentary glaucoma. Mastropasqua, L., Carpineto, P., Ciancaglini, M., Gallenga, P.E. Ophthalmology (1999) [Pubmed]
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