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MeSH Review

Intraocular Pressure

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Disease relevance of Intraocular Pressure


Psychiatry related information on Intraocular Pressure


High impact information on Intraocular Pressure


Chemical compound and disease context of Intraocular Pressure


Biological context of Intraocular Pressure


Anatomical context of Intraocular Pressure


Associations of Intraocular Pressure with chemical compounds


Gene context of Intraocular Pressure

  • Carbonic anhydrase (CA) activity plays an important role in controlling aqueous humor production in the eye and in regulating intraocular pressure [31].
  • In addition, APOE(-491T), interacting at a highly significant level with an SNP in the MYOC promoter, MYOC(-1000G), is associated with increased intraocular pressure (IOP) and with limited effectiveness of IOP-lowering treatments in patients with POAG [32].
  • However, because humans with defective AQP1 are phenotypically normal and because the ocular application of phorbol esters reduce intraocular pressure, we postulated that the water channel activity of AQP4 may be regulated by these agents [33].
  • Although ET-1-induced PG release could function to modulate, through cAMP, the responses to muscarinic receptor stimulation, the precise role of these effects in intraocular pressure lowering and accommodation remains to be delineated [34].
  • The present study tested whether OPTN sequence changes play a role in early-onset glaucoma characterized by elevated intraocular pressure [35].

Analytical, diagnostic and therapeutic context of Intraocular Pressure


  1. Prevalence of increased intraocular pressure in Graves' disease--evidence of frequent subclinical ophthalmopathy. Gamblin, G.T., Harper, D.G., Galentine, P., Buck, D.R., Chernow, B., Eil, C. N. Engl. J. Med. (1983) [Pubmed]
  2. Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. Weinstein, B.I., Gordon, G.G., Southren, A.L. Science (1983) [Pubmed]
  3. Juvenile glaucoma, race, and refraction. Lotufo, D., Ritch, R., Szmyd, L., Burris, J.E. JAMA (1989) [Pubmed]
  4. Corticosteroid treatment for inflammatory bowel disease in pediatric patients increases intraocular pressure. Tripathi, R.C., Kirschner, B.S., Kipp, M., Tripathi, B.J., Slotwiner, D., Borisuth, N.S., Karrison, T., Ernest, J.T. Gastroenterology (1992) [Pubmed]
  5. Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exudative, and neovascular diseases. Jonas, J.B., Kreissig, I., Degenring, R. Progress in retinal and eye research. (2005) [Pubmed]
  6. Latanoprost and timolol combination therapy vs monotherapy: one-year randomized trial. Higginbotham, E.J., Feldman, R., Stiles, M., Dubiner, H. Arch. Ophthalmol. (2002) [Pubmed]
  7. Electroconvulsive therapy and intraocular pressure. Van Den Berg, A.A., Honjol, N.M. Middle East journal of anesthesiology. (1998) [Pubmed]
  8. Nasal CPAP during wakefulness increases intraocular pressure in glaucoma. Alvarez-Sala, R., García, I.T., García, F., Moriche, J., Prados, C., Díaz, S., Villasante, C., Alvarez-Sala, J.L., Villamor, J. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. (1994) [Pubmed]
  9. Ocular manifestations of gravity inversion. Friberg, T.R., Weinreb, R.N. JAMA (1985) [Pubmed]
  10. Eye drops of RU 486-6, a peripheral steroid blocker, lower intraocular pressure in rabbits. Phillips, C.I., Green, K., Gore, S.M., Cullen, P.M., Campbell, M. Lancet (1984) [Pubmed]
  11. Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels. Mekki, Q.A., Warrington, S.J., Turner, P. Lancet (1984) [Pubmed]
  12. Bromocriptine lowers intraocular pressure without affecting blood pressure. Mekki, Q.A., Hassan, S.M., Turner, P. Lancet (1983) [Pubmed]
  13. Forskolin lowers intraocular pressure in rabbits, monkeys, and man. Caprioli, J., Sears, M. Lancet (1983) [Pubmed]
  14. Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans. Elliott, W.J., Karnezis, T.A., Silverman, R.A., Geanon, J., Tripathi, R.C., Murphy, M.B. Clin. Pharmacol. Ther. (1991) [Pubmed]
  15. Lack of long-term drift in timolol's effectiveness in patients with ocular hypertension. Bengtsson, B., Heijl, A. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  16. Effect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension. Orzalesi, N., Rossetti, L., Invernizzi, T., Bottoli, A., Autelitano, A. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  17. Timolol: a review of its therapeutic efficacy in the topical treatment of glaucoma. Heel, R.C., Brogden, R.N., Speight, T.M., Avery, G.S. Drugs (1979) [Pubmed]
  18. Acute effects of dexamethasone on intraocular pressure in glaucoma. Weinreb, R.N., Polansky, J.R., Kramer, S.G., Baxter, J.D. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  19. Hemodynamic and non-bronchial effects of ipratropium bromide. Anderson, W.M. Am. J. Med. (1986) [Pubmed]
  20. Dynamics and kinetics of ophthalmic timolol. Affrime, M.B., Lowenthal, D.T., Tobert, J.A., Shirk, J., Eidelson, B., Cook, T., Onesti, G. Clin. Pharmacol. Ther. (1980) [Pubmed]
  21. Optic nerve oxygenation. Stefánsson, E., Pedersen, D.B., Jensen, P.K., la Cour, M., Kiilgaard, J.F., Bang, K., Eysteinsson, T. Progress in retinal and eye research. (2005) [Pubmed]
  22. Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium. Nathanson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  23. Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Jacobson, N., Andrews, M., Shepard, A.R., Nishimura, D., Searby, C., Fingert, J.H., Hageman, G., Mullins, R., Davidson, B.L., Kwon, Y.H., Alward, W.L., Stone, E.M., Clark, A.F., Sheffield, V.C. Hum. Mol. Genet. (2001) [Pubmed]
  24. Selective upregulation of the A3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucoma. Schlötzer-Schrehardt, U., Zenkel, M., Decking, U., Haubs, D., Kruse, F.E., Jünemann, A., Coca-Prados, M., Naumann, G.O. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  25. Topical application of serotonin or the 5-HT1-agonist 5-CT intraocular pressure in rabbits. Meyer-Bothling, U., Bron, A.J., Osborne, N.N. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  26. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Guo, L., Moss, S.E., Alexander, R.A., Ali, R.R., Fitzke, F.W., Cordeiro, M.F. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  27. Cyclic AMP and intraocular pressure. Rushton, A. Lancet (1983) [Pubmed]
  28. Effect of sotalol on normal intraocular pressure. Crick, R.P., Reynolds, P. Lancet (1980) [Pubmed]
  29. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. Kunapuli, P., Lawson, J.A., Rokach, J., FitzGerald, G.A. J. Biol. Chem. (1997) [Pubmed]
  30. Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4. Peterson, J.A., Sheibani, N., David, G., Garcia-Pardo, A., Peters, D.M. J. Biol. Chem. (2005) [Pubmed]
  31. Localization of carbonic anhydrase IV in a specific capillary bed of the human eye. Hageman, G.S., Zhu, X.L., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  32. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Copin, B., Brézin, A.P., Valtot, F., Dascotte, J.C., Béchetoille, A., Garchon, H.J. Am. J. Hum. Genet. (2002) [Pubmed]
  33. Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation. Han, Z., Wax, M.B., Patil, R.V. J. Biol. Chem. (1998) [Pubmed]
  34. Prostaglandins mediate the stimulatory effects of endothelin-1 on cyclic adenosine monophosphate accumulation in ciliary smooth muscle isolated from bovine, cat, and other mammalian species. Abdel-Latif, A.A., Yousufzai, S.Y., el-Mowafy, A.M., Ye, Z. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  35. Defining the pathogenicity of optineurin in juvenile open-angle glaucoma. Willoughby, C.E., Chan, L.L., Herd, S., Billingsley, G., Noordeh, N., Levin, A.V., Buys, Y., Trope, G., Sarfarazi, M., Héon, E. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  36. Essential fatty acid deficiency in total parenteral nutrition. Detection by changes in intraocular pressure. Freund, H., Floman, N., Schwartz, B., Fischer, J.E. Ann. Surg. (1979) [Pubmed]
  37. Vanadate and aqueous humor dynamics. Proctor Lecture. Becker, B. Invest. Ophthalmol. Vis. Sci. (1980) [Pubmed]
  38. Uveoscleral aqueous outflow in the rhesus monkey: importance of uveal reabsorption. Pederson, J.E., Gaasterland, D.E., MacLellan, H.M. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  39. Variability in choriocapillaris blood flow distribution. Flower, R.W., Fryczkowski, A.W., McLeod, D.S. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  40. Tonometric changes of latanoprost-induced intraocular pressure reduction after photorefractive keratectomy. Tamburrelli, C., Vaiano, A.S., Salgarello, T., Caputo, C.G., Scullica, L. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
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