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Gene Review: 

MOCS3  -  molybdenum cofactor synthesis 3

Homo sapiens

Synonyms: Adenylyltransferase and sulfurtransferase MOCS3, MPT synthase sulfurylase, Molybdenum cofactor synthesis protein 3, Molybdopterin synthase sulfurylase, UBA4, ...
 
 
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Disease relevance of MOCS3

  • The human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein and a C-terminal segment displaying similarities to the sulfurtransferase rhodanese [1].
 

High impact information on MOCS3

  • The human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein and a C-terminal segment displaying similarities to the sulfurtransferase rhodanese [2].
  • In contrast to other mammalian rhodaneses, which are mostly localized within mitochondria, MOCS3 in addition to the subunits of MPT synthase are localized in the cytosol [2].
  • Recent studies have shown that the MOCS3 rhodanese-like domain (MOCS3-RLD) catalyzes the transfer of sulfur from thiosulfate to cyanide and is also able to provide the sulfur for the thiocarboxylation of MOCS2A in a defined in vitro system for the generation of MPT from precursor Z [1].

References

  1. Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. Matthies, A., Nimtz, M., Leimkühler, S. Biochemistry (2005) [Pubmed]
  2. Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans. Matthies, A., Rajagopalan, K.V., Mendel, R.R., Leimkühler, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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