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Abca7  -  ATP-binding cassette, sub-family A (ABC1),...

Mus musculus

Synonyms: ABCX, ATP-binding cassette sub-family A member 7, Abc51
 
 
 
 
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High impact information on Abca7

  • Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels [1].
  • Cholesterol and phospholipid efflux stimulated by apolipoprotein A-I from macrophages isolated from wild type and Abca7-/- mice did not differ, suggesting that these activities may not be central to the physiological role of the transporter in vivo [1].
  • Abca7-/- females, but not males, had significantly less visceral fat and lower total serum and high density lipoprotein cholesterol levels than wild type, gender-matched littermates [1].

References

  1. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. Kim, W.S., Fitzgerald, M.L., Kang, K., Okuhira, K., Bell, S.A., Manning, J.J., Koehn, S.L., Lu, N., Moore, K.J., Freeman, M.W. J. Biol. Chem. (2005) [Pubmed]
 
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