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Gene Review

ABCA7  -  ATP-binding cassette, sub-family A (ABC1),...

Homo sapiens

Synonyms: ABCA-SSN, ABCX, ATP-binding cassette sub-family A member 7, Autoantigen SS-N, Macrophage ABC transporter
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Disease relevance of ABCA7

  • We found that this amino-terminal extracellular domain contains a segment homologous to the autoantigen SS-N, an epitope of Sjögren's syndrome, and further identified that ABCA7 codes for the autoantigen SS-N [1].
  • ECD1 of human ABCA7 (amino acids 45-549) was expressed in Escherichia coli as a protein fused with glutathione-S-transferase and a monoclonal antibody, KM3095, was generated [2].
  • This study investigated (1) the differential impact of the child's chronic illness (CI) on 80 fathers and 80 mothers and the psychosocial variables contributing to their adaptation and (2) the suitability of the causal model based on the Double ABCX Model to predict parents' adaptation to the child's illness [3].

Psychiatry related information on ABCA7

  • This study examined the factors that contribute to empowerment in parents of school-aged children with and without developmental disabilities (DD) using the Double ABCX model of family adaptation contrasted with the linear ACBX model [4].
  • Adjustment in mothers of children with Asperger syndrome: an application of the double ABCX model of family adjustment [5].
  • Coping with stress in families with children who have mental retardation: an evaluation of the double ABCX model [6].
  • Mothers of children with autism or communication disorders: successful adaptation and the double ABCX model [7].
  • This study demonstrates the effectiveness of a modified Double ABCX or FAAR model in predicting successful adaptation--good marital adjustment, few maternal depressive symptoms, and an in-home rating of family functioning--in 45 families of autistic and communication-impaired children [7].

High impact information on ABCA7


Biological context of ABCA7


Anatomical context of ABCA7


Associations of ABCA7 with chemical compounds

  • Chimeric transporters, generated by substituting the C termini of either ABCA4 or ABCA7 for the endogenous terminus, demonstrated that ABCA1 could stimulate cholesterol efflux without its PDZ-binding motif but not without the VFVNFA motif [16].
  • Given the observation that during terminal keratinocyte differentiation intracellular and surface ceramide levels are increased, our results render ABCA7 a candidate regulator of ceramide transport in this process [13].
  • Expression of both ABCA1 and ABCA7 was induced linearly proportional to ponasterone A concentration in the medium [17].
  • We analyzed the promoter of the ABCA7 gene and identified the new exon encoding 96 bp (mouse) and 95 bp (human) of the 5' untranslated region and the transcription start site at 1,122 bp (mouse) and 1,260 bp (human) upstream of the initiation methionine codon [18].

Physical interactions of ABCA7


Other interactions of ABCA7


Analytical, diagnostic and therapeutic context of ABCA7

  • RT-PCR experiments suggested that human ABCA7 gene produced the type II mRNA in a tissue-specific manner [11].
  • Surprisingly, sequence analysis of the ABCA7 3' gene flanking region revealed that the terminal exon of ABCA7 borders immediately on the 5' end of the coding region of the recently identified human minor histocompatibility antigen HA-1 [10].
  • Strikingly, immunofluorescence studies of adult mouse kidney revealed an apical brush border membrane localization of ABCA7 in the proximal tubule, suggesting that ABCA7 may come in contact with apoA-I in the glomerular filtrate [22].
  • METHODS: Ninety consecutive patients undergoing primary angioplasty with coronary stenting were randomized in a sequential alternating fashion to standard abciximab treatment (ABCX) group, intracoronary adenosine distal to the occlusion (ADO) group, or neither (CTRL) group [23].


  1. Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome. Tanaka, A.R., Ikeda, Y., Abe-Dohmae, S., Arakawa, R., Sadanami, K., Kidera, A., Nakagawa, S., Nagase, T., Aoki, R., Kioka, N., Amachi, T., Yokoyama, S., Ueda, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Detection of ABCA7-positive cells in salivary glands from patients with Sjögren's syndrome. Toda, Y., Aoki, R., Ikeda, Y., Azuma, Y., Kioka, N., Matsuo, M., Sakamoto, M., Mori, S., Fukumoto, M., Ueda, K. Pathol. Int. (2005) [Pubmed]
  3. Gender differences in adapting to a child's chronic illness: a causal model. Katz, S. Journal of pediatric nursing. (2002) [Pubmed]
  4. Empowerment in parents of school-aged children with and without developmental disabilities. Nachshen, J.S., Minnes, P. Journal of intellectual disability research : JIDR. (2005) [Pubmed]
  5. Adjustment in mothers of children with Asperger syndrome: an application of the double ABCX model of family adjustment. Pakenham, K.I., Samios, C., Sofronoff, K. Autism : the international journal of research and practice. (2005) [Pubmed]
  6. Coping with stress in families with children who have mental retardation: an evaluation of the double ABCX model. Orr, R.R., Cameron, S.J., Day, D.M. American journal of mental retardation : AJMR. (1991) [Pubmed]
  7. Mothers of children with autism or communication disorders: successful adaptation and the double ABCX model. Bristol, M.M. Journal of autism and developmental disorders. (1987) [Pubmed]
  8. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. Jehle, A.W., Gardai, S.J., Li, S., Linsel-Nitschke, P., Morimoto, K., Janssen, W.J., Vandivier, R.W., Wang, N., Greenberg, S., Dale, B.M., Qin, C., Henson, P.M., Tall, A.R. J. Cell Biol. (2006) [Pubmed]
  9. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. Kim, W.S., Fitzgerald, M.L., Kang, K., Okuhira, K., Bell, S.A., Manning, J.J., Koehn, S.L., Lu, N., Moore, K.J., Freeman, M.W. J. Biol. Chem. (2005) [Pubmed]
  10. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Kaminski, W.E., Piehler, A., Schmitz, G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  11. Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Ikeda, Y., Abe-Dohmae, S., Munehira, Y., Aoki, R., Kawamoto, S., Furuya, A., Shitara, K., Amachi, T., Kioka, N., Matsuo, M., Yokoyama, S., Ueda, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  12. Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Broccardo, C., Osorio, J., Luciani, M.F., Schriml, L.M., Prades, C., Shulenin, S., Arnould, I., Naudin, L., Lafargue, C., Rosier, M., Jordan, B., Mattei, M.G., Dean, M., Denèfle, P., Chimini, G. Cytogenet. Cell Genet. (2001) [Pubmed]
  13. Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. Kielar, D., Kaminski, W.E., Liebisch, G., Piehler, A., Wenzel, J.J., Möhle, C., Heimerl, S., Langmann, T., Friedrich, S.O., Böttcher, A., Barlage, S., Drobnik, W., Schmitz, G. J. Invest. Dermatol. (2003) [Pubmed]
  14. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Kim, W.S., Guillemin, G.J., Glaros, E.N., Lim, C.K., Garner, B. Neuroreport (2006) [Pubmed]
  15. The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. Mack, J.T., Townsend, D.M., Beljanski, V., Tew, K.D. Curr. Drug Metab. (2007) [Pubmed]
  16. ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. Fitzgerald, M.L., Okuhira, K., Short, G.F., Manning, J.J., Bell, S.A., Freeman, M.W. J. Biol. Chem. (2004) [Pubmed]
  17. Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. Hayashi, M., Abe-Dohmae, S., Okazaki, M., Ueda, K., Yokoyama, S. J. Lipid Res. (2005) [Pubmed]
  18. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. Iwamoto, N., Abe-Dohmae, S., Sato, R., Yokoyama, S. J. Lipid Res. (2006) [Pubmed]
  19. Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome. Harangi, M., Kaminski, W.E., Fleck, M., Orsó, E., Zeher, M., Kiss, E., Szekanecz, Z., Zilahi, E., Marienhagen, J., Aslanidis, C., Paragh, G., Bolstad, A.I., Jonsson, R., Schmitz, G. Eur. J. Immunol. (2005) [Pubmed]
  20. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi, M., Ishibashi, K., Ando, H., Kasanuki, H., Tsuruoka, S. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
  21. Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner. Abe-Dohmae, S., Kato, K.H., Kumon, Y., Hu, W., Ishigami, H., Iwamoto, N., Okazaki, M., Wu, C.A., Tsujita, M., Ueda, K., Yokoyama, S. J. Lipid Res. (2006) [Pubmed]
  22. Potential role of ABCA7 in cellular lipid efflux to apoA-I. Linsel-Nitschke, P., Jehle, A.W., Shan, J., Cao, G., Bacic, D., Lan, D., Wang, N., Tall, A.R. J. Lipid Res. (2005) [Pubmed]
  23. Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine. Petronio, A.S., De Carlo, M., Ciabatti, N., Amoroso, G., Limbruno, U., Palagi, C., Di Bello, V., Romano, M.F., Mariani, M. Am. Heart J. (2005) [Pubmed]
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