The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Nelfe  -  negative elongation factor complex member...

Mus musculus

Synonyms: D17H6S45, D17h6s45, NELF-E, Negative elongation factor E, RD, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Rdbp

  • The R5 (chemotype Rb) but not the R10 (chemotype Rd) mutant of murine pathogen Salmonella typhimurium 395MS was extremely virulent in intraperitoneal infections of C57BL/10ScCr mice carrying the ityS and lpsD alleles [1].
 

High impact information on Rdbp

  • Further studies revealed that the two adjacent genes, complement component C2 and D17H6S45, had been down regulated as a result of the disruption [2].
  • Virulence of the RD mutant in either normal or iron-overloaded mice challenged by intraperitoneal injection was comparable to that of the parent strain, indicating that SmcR is not required for V. vulnificus virulence in mice [3].
  • Rd mutant mice are visually blind but they maintain the ability of synchronising their circadian rhythms to the external light-dark cycles [4].
  • Murine D17H6S45 (Rd) gene: polymorphism and overlap with complement factor B [5].
  • Moreover, both MPL and DPL enhanced antibody production significantly in the endotoxin low-responder mouse strains C3H/HeJ and C57Bl/10 ScN, whereas phenol-water-extracted endotoxin from an Rd mutant was ineffective [6].

References

  1. Susceptibility of lipopolysaccharide-responsive and -hyporesponsive ItyS Mice to infection with rough mutants of Salmonella typhimurium. Mattsby-Baltzer, I., Ahlström, B., Edebo, L., de Man, P. Infect. Immun. (1996) [Pubmed]
  2. A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45. Taylor, P.R., Nash, J.T., Theodoridis, E., Bygrave, A.E., Walport, M.J., Botto, M. J. Biol. Chem. (1998) [Pubmed]
  3. Regulation of metalloprotease gene expression in Vibrio vulnificus by a Vibrio harveyi LuxR homologue. Shao, C.P., Hor, L.I. J. Bacteriol. (2001) [Pubmed]
  4. Spatio-temporal analysis of light-induced Fos expression in the retina of rd mutant mice. Huerta, J.J., Llamosas, M.M., Cernuda-Cernuda, R., García-Fernández, J.M. Brain Res. (1999) [Pubmed]
  5. Murine D17H6S45 (Rd) gene: polymorphism and overlap with complement factor B. Taylor, P.R., Slingsby, J.H., Walport, M.J., Botto, M. Mamm. Genome (1997) [Pubmed]
  6. The adjuvant properties of a nontoxic monophosphoryl lipid A in hyporesponsive and aging mice. Tomai, M.A., Solem, L.E., Johnson, A.G., Ribi, E. Journal of biological response modifiers. (1987) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities