Gene Review:
Cfb - complement factor B
Mus musculus
Synonyms:
AI195813, AI255840, Bf, C2, C3/C5 convertase, ...
- Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Persson, L., Borén, J., Robertson, A.K., Wallenius, V., Hansson, G.K., Pekna, M. Arterioscler. Thromb. Vasc. Biol. (2004)
- Factor B, the complement alternative pathway serine proteinase, is a major constitutive protein synthesized and secreted by resident and elicited mouse macrophages. Sundsmo, J.S., Chin, J.R., Papin, R.A., Fair, D.S., Werb, Z. J. Exp. Med. (1985)
- Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis. Passwell, J., Schreiner, G.F., Nonaka, M., Beuscher, H.U., Colten, H.R. J. Clin. Invest. (1988)
- Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Matsumoto, M., Fukuda, W., Circolo, A., Goellner, J., Strauss-Schoenberger, J., Wang, X., Fujita, S., Hidvegi, T., Chaplin, D.D., Colten, H.R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Constitutive expression of murine complement factor B gene is regulated by the interaction of its upstream promoter with hepatocyte nuclear factor 4. Garnier, G., Circolo, A., Colten, H.R. J. Biol. Chem. (1996)
- Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Pickering, M.C., Cook, H.T., Warren, J., Bygrave, A.E., Moss, J., Walport, M.J., Botto, M. Nat. Genet. (2002)
- Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs. Goundis, D., Reid, K.B. Nature (1988)
- Biosynthesis of membrane factor B by mouse peritoneal macrophages. Ooi, Y.M., Ooi, B.S. Nature (1982)
- Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. Watanabe, H., Garnier, G., Circolo, A., Wetsel, R.A., Ruiz, P., Holers, V.M., Boackle, S.A., Colten, H.R., Gilkeson, G.S. J. Immunol. (2000)
- Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. Saeland, E., Vidarsson, G., Leusen, J.H., Van Garderen, E., Nahm, M.H., Vile-Weekhout, H., Walraven, V., Stemerding, A.M., Verbeek, J.S., Rijkers, G.T., Kuis, W., Sanders, E.A., Van De Winkel, J.G. J. Immunol. (2003)
- Complement gene expression in hepatic and extrahepatic tissues of NZB and NZB x W (F1) mouse strains. Passwell, J.H., Schreiner, G.F., Wetsel, R.A., Colten, H.R. Immunology (1990)
- Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Momota, H., Nerio, E., Holland, E.C. Cancer Res. (2005)
- On the mechanism of antiinflammation induced by tumor transplantation, surgery, and irritant injection. Normann, S., Besedovsky, H., Schardt, M., del Rey, A. J. Leukoc. Biol. (1991)
- Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J.M., Kraus, D., Hollmann, T.J., Casali, P., Caroll, M.C., Wetsel, R.A., Lambris, J.D., Holers, V.M., Salmon, J.E. J. Clin. Invest. (2003)
- Effects of complement factor D deficiency on the renal disease of MRL/lpr mice. Elliott, M.K., Jarmi, T., Ruiz, P., Xu, Y., Holers, V.M., Gilkeson, G.S. Kidney Int. (2004)
- Ovarian steroid-regulated synthesis and secretion of complement C3 and factor B in mouse endometrium during the natural estrous cycle and pregnancy period. Li, S.H., Huang, H.L., Chen, Y.H. Biol. Reprod. (2002)
- Structural polymorphism of murine factor B controlled by a locus closely linked to the H-2 complex and demonstration of multiple alleles. Natsuume-Sakai, S., Moriwaki, K., Migita, S., Sudo, K., Suzuki, K., Lu, D.Y., Wang, C., Takahashi, M. Immunogenetics (1983)
- A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45. Taylor, P.R., Nash, J.T., Theodoridis, E., Bygrave, A.E., Walport, M.J., Botto, M. J. Biol. Chem. (1998)
- Regulation of alternative pathway activation and C3a production by adipose cells. Choy, L.N., Spiegelman, B.M. Obes. Res. (1996)
- Detection and quantification of the control proteins of the alternative pathway of complement in 3T3-L1 adipocytes. Peake, P.W., O'Grady, S., Pussell, B.A., Charlesworth, J.A. Eur. J. Clin. Invest. (1997)
- Isolation and properties of a complement inhibitor from Naja haje venom, distinct from known anticomplementary factors in cobra venom. von Zabern, I., Przyklenk, H., Damerau, B., Zimmermann, B. Scand. J. Immunol. (1981)
- Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. Bora, N.S., Kaliappan, S., Jha, P., Xu, Q., Sohn, J.H., Dhaulakhandi, D.B., Kaplan, H.J., Bora, P.S. J. Immunol. (2006)
- Complement factor B gene regulation: synergistic effects of TNF-alpha and IFN-gamma in macrophages. Huang, Y., Krein, P.M., Muruve, D.A., Winston, B.W. J. Immunol. (2002)
- The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice. Tang, J., Kozaki, K., Farr, A.G., Martin, P.J., Lindahl, P., Betsholtz, C., Raines, E.W. Am. J. Pathol. (2005)
- Expression of the MHC class III genes. Colten, H.R. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1984)
- Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation. Mitchell, D.A., Taylor, P.R., Cook, H.T., Moss, J., Bygrave, A.E., Walport, M.J., Botto, M. J. Immunol. (1999)
- Tissue-specific initiation of murine complement factor B mRNA transcription. Nonaka, M., Ishikawa, N., Passwell, J., Natsuume-Sakai, S., Colten, H.R. J. Immunol. (1989)