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Gene Review

argJ  -  bifunctional ornithine acetyltransferase/N...

Thermus thermophilus HB27

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Disease relevance of argJ


High impact information on argJ

  • Both upstream of the argC gene and downstream of the argJ gene an ORF with unknown function was found, indicating that the organization of the arginine biosynthetic genes in T. thermophilus is new [1].
  • The argJ-encoded enzyme activity was twofold repressed by arginine in the native host and was inhibited by ornithine [1].

Analytical, diagnostic and therapeutic context of argJ

  • Sequence analysis of the pTHM1 3.2 kb insert revealed the presence of the argC gene (encoding N-acetylglutamate-5-semialdehyde dehydrogenase) upstream of the argJ gene [1].


  1. Genes and enzymes of the acetyl cycle of arginine biosynthesis in the extreme thermophilic bacterium Thermus thermophilus HB27. Baetens, M., Legrain, C., Boyen, A., Glansdorff, N. Microbiology (Reading, Engl.) (1998) [Pubmed]
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