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Gene Review

NRG1  -  neuregulin 1

Bos taurus

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High impact information on NRG1

  • PC12 cells chronically treated with NRG-1 (beta1 isoform) show an increase in proliferation under low-serum condition (2.5% fetal bovine serum and 1.25% horse serum) and serum deprivation, without visible morphological changes [1].
  • Neuregulin-1 (NRG-1) is an active component found in sciatic nerve conditioned medium (CM) [1].


  1. Neuregulin-1 isoform induces mitogenesis, K(Ca) and Ca(2+) currents in PC12 cells. A comparison with sciatic nerve conditioned medium. Castillo, C., Malavé, C., Martínez, J.C., Núñez, J., Hernández, D., Pasquali, F., Villegas, G.M., Villegas, R. Brain Res. (2006) [Pubmed]
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