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Gene Review: 

TYMS  -  thymidylate synthetase

Bos taurus

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Disease relevance of TYMS

  • The adsorption of thymidylate synthetase from Escherichia coli B to aminoalkyl-Sepharose with the increasing length of carbon chain (2--6 carbon atoms) was investigated [1].
  • The purification procedure was applied to a crude thymidylate synthetase preparation from resting E. coli, calf thymus, Sarcoma 180, and Gardner lymphosarcoma [1].
 

High impact information on TYMS

  • Compounds 5a,b,d were converted to the respective 5'-phosphates 6a,b,d. All three compounds were subtrate competitive inhibitors of thymidylate synthetase purified from Escherichia coli, calf thymus, and Ehrlich ascites tumor cells [2].
  • RESULTS: In vitro, MTX dose dependently increased the uptake of [3H]-thymidine, and decreased incorporation of [3H]-d-uridine into chondrocytes with a half maximal effect at 0.03 microM, suggesting inhibition of thymidylate-synthetase activity by the drug [3].
 

Analytical, diagnostic and therapeutic context of TYMS

References

  1. Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography. Slavík, K., Rode, W., Slavíková, V. Biochemistry (1976) [Pubmed]
  2. Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates. Edelman, M.S., Barfknecht, R.L., Huet-Rose, R., Boguslawski, S., Mertes, M.P. J. Med. Chem. (1977) [Pubmed]
  3. Effects of methotrexate on normal articular cartilage in vitro and in vivo. Neidel, J., Sova, L., Schroers, B., Sintermann, F., Manzke, O., Bohlen, H. Ann. Rheum. Dis. (1998) [Pubmed]
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