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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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PDIA3  -  protein disulfide isomerase family A,...

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Disease relevance of GRP58

  • BVDV cDNA fragments predicted to encode part of NS4B/P38 (from codon 2521 to 2838 of the BVDV open reading frame) and a portion of NS5A/P58 (from codon 3008 to 3340) were expressed as glutathione S-transferase (GST) fusion proteins in Escherichia coli [1].
 

High impact information on GRP58

 

Analytical, diagnostic and therapeutic context of GRP58

  • Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation [3].
  • Confocal microscopy showed that in BVDV infected cells, NS3 and/or NS2-3 co-localise with the endoplasmic reticulum (ER) protein, ERP60, but not Golgi or lysosomal proteins [4].

References

  1. Identification of bovine viral diarrhea virus nonstructural polypeptide NS4B/P38. van Olphen, A.L., Donis, R.O. Virus Res. (1997) [Pubmed]
  2. Erp61 is GRP58, a stress-inducible luminal endoplasmic reticulum protein, but is devoid of phosphatidylinositide-specific phospholipase C activity. Mazzarella, R.A., Marcus, N., Haugejorden, S.M., Balcarek, J.M., Baldassare, J.J., Roy, B., Li, L.J., Lee, A.S., Green, M. Arch. Biochem. Biophys. (1994) [Pubmed]
  3. Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation. Hirano, N., Shibasaki, F., Sakai, R., Tanaka, T., Nishida, J., Yazaki, Y., Takenawa, T., Hirai, H. Eur. J. Biochem. (1995) [Pubmed]
  4. Differences in membrane association and sub-cellular distribution between NS2-3 and NS3 of bovine viral diarrhoea virus. Zhang, G., Flick-Smith, H., McCauley, J.W. Virus Res. (2003) [Pubmed]
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