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Gene Review

PDIA3  -  protein disulfide isomerase family A,...

Gallus gallus

Synonyms: 25D3-membrane-associated, 58kDa, ERp57, GRP58
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High impact information on PDIA3

  • We now report the complete sequence of the cloned chicken cDNA for the 1,25D(3)-MARRS (membrane-associated, rapid-response steroid-binding) protein and reveal it to be identical to the multifunctional protein ERp57 [1].
  • Moreover, the molecular basis of such inhibition was suggested by the presence of two thioredoxin domains in the 1,25D(3)-MARRS protein/ERp57: Exposure of cells to either 24,25(OH)(2)D(3) or H(2)O(2) gradually reduced 1,25(OH)(2)D(3) binding to 1,25D(3)-MARRS protein, between 10 and 20 min of incubation, but not to VDR [2].


  1. Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells. Nemere, I., Farach-Carson, M.C., Rohe, B., Sterling, T.M., Norman, A.W., Boyan, B.D., Safford, S.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Mechanism of 24,25-dihydroxyvitamin D(3)-mediated inhibition of rapid, 1,25-dihydroxyvitamin D(3)-induced responses: Role of reactive oxygen species. Nemere, I., Wilson, C., Jensen, W., Steinbeck, M., Rohe, B., Farach-Carson, M.C. J. Cell. Biochem. (2006) [Pubmed]
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