Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ANCR - Angelman syndrome chromosome region

Homo sapiens

Dittrich, B. et al., Chen, W. et al., Hou, J.W. et al., Huang, B. et al.

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Disease relevance of ANCR

Infections of the disease-susceptible ANCR or -resistant C57BL/6 mice with the K1L-lacking ectromelia virus yielded a pathogenesis pattern indistinguishable from wild-type, suggesting that the ectromelia virus homolog of vaccinia virus K1L is not important for ectromelia virus in vivo replication and spread [1].

High impact information on ANCR

Characterization of a DNA sequence family in the Prader-Willi/Angelman syndrome chromosome region in 15q11-q13 [2].
Fluorescence in situ hybridization (FISH) analysis using D15Z, D15Z1, and the cosmids from the Prader-Willi/Angelman syndrome chromosome region (PW/ASCR) was performed on 54 patients (0.45%) with ESACs from 11893 probands within a 5-year period [3].
Fluorescence in situ hybridization with probes rRNA, D15Z4, D15S11, and GABRB3 demonstrated that both markers were chromosome 15 in origin and contained the Prader-Willi/Angelman syndrome chromosome region [4].

Analytical, diagnostic and therapeutic context of ANCR

Using YAC cloning and restriction enzyme analysis, we have found that IR4-3R detects five related DNA sequences, which are spread over 700 kb within the Prader-Willi/Angelman syndrome chromosome region in 15q11-q13 [2].

References

In vitro and in vivo study of the ectromelia virus homolog of the vaccinia virus K1L host range gene. Chen, W., Drillien, R., Spehner, D., Buller, R.M. Virology (1993) [Pubmed]
Characterization of a DNA sequence family in the Prader-Willi/Angelman syndrome chromosome region in 15q11-q13. Dittrich, B., Knoblauch, H., Buiting, K., Horsthemke, B. Genomics (1993) [Pubmed]
Unusual features in children with inv dup(15) supernumerary marker: a study of genotype-phenotype correlation in Taiwan. Hou, J.W., Wang, T.R. Eur. J. Pediatr. (1998) [Pubmed]
Partial hexasomy of chromosome 15. Huang, B., Bartley, J. Am. J. Med. Genet. A (2003) [Pubmed]

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