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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COL2A1  -  collagen, type II, alpha 1

Bos taurus

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Disease relevance of COL2A1

  • Collagen II (COL2A1) was down-regulated by hypoxia but aggrecan mRNA levels remained unchanged [1].
 

High impact information on COL2A1

 

Biological context of COL2A1

  • RESULTS: We selected a culture for 15 or 17 days with collagen sponges seeded with 10(7) chondrocytes showing a minimal cell proliferation, a maximal sulphated glycosaminoglycan (sGAG) deposition and a high expression of COL2A1, aggrecan and the alpha10 integrin sub-unit and low expression of COL1A2 and the alpha11 integrin sub-unit [3].

References

  1. Modulation of bovine articular chondrocyte gene expression in vitro by oxygen tension. Grimshaw, M.J., Mason, R.M. Osteoarthr. Cartil. (2001) [Pubmed]
  2. Bovine chondrocyte behaviour in three-dimensional type I collagen gel in terms of gel contraction, proliferation and gene expression. Galois, L., Hutasse, S., Cortial, D., Rousseau, C.F., Grossin, L., Ronziere, M.C., Herbage, D., Freyria, A.M. Biomaterials (2006) [Pubmed]
  3. Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis. Cortial, D., Gouttenoire, J., Rousseau, C.F., Ronzière, M.C., Piccardi, N., Msika, P., Herbage, D., Mallein-Gerin, F., Freyria, A.M. Osteoarthr. Cartil. (2006) [Pubmed]
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