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Gene Review

EPAS1  -  endothelial PAS domain protein 1

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Disease relevance of EPAS1

  • Since VEGF plays a crucial role in angiogenesis, the ability of dominant-negative EPAS1 to inhibit VEGF promoter activity raises the possibility of a novel approach to inhibiting pathological angiogenesis [1].

High impact information on EPAS1


  1. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. Maemura, K., Hsieh, C.M., Jain, M.K., Fukumoto, S., Layne, M.D., Liu, Y., Kourembanas, S., Yet, S.F., Perrella, M.A., Lee, M.E. J. Biol. Chem. (1999) [Pubmed]
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