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Gene Review

VEGFA  -  vascular endothelial growth factor A

Bos taurus

Synonyms: VEGF, VEGF-A, VPF, eVEGF120, eVEGF164
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Disease relevance of VEGF


Psychiatry related information on VEGF


High impact information on VEGF


Chemical compound and disease context of VEGF


Biological context of VEGF


Anatomical context of VEGF


Associations of VEGF with chemical compounds


Physical interactions of VEGF


Regulatory relationships of VEGF


Other interactions of VEGF


Analytical, diagnostic and therapeutic context of VEGF


  1. PEDF derived from glial Müller cells: a possible regulator of retinal angiogenesis. Eichler, W., Yafai, Y., Keller, T., Wiedemann, P., Reichenbach, A. Exp. Cell Res. (2004) [Pubmed]
  2. Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Platt, D.H., Bartoli, M., El-Remessy, A.B., Al-Shabrawey, M., Lemtalsi, T., Fulton, D., Caldwell, R.B. Free Radic. Biol. Med. (2005) [Pubmed]
  3. Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma. Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H., Hamanishi, C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. The effects of ionizing radiation on osteoblast-like cells in vitro. Dudziak, M.E., Saadeh, P.B., Mehrara, B.J., Steinbrech, D.S., Greenwald, J.A., Gittes, G.K., Longaker, M.T. Plast. Reconstr. Surg. (2000) [Pubmed]
  5. Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide. Mamputu, J.C., Renier, G. J. Diabetes Complicat. (2002) [Pubmed]
  6. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. Lee, M.C., El-Sakka, A.I., Graziottin, T.M., Ho, H.C., Lin, C.S., Lue, T.F. J. Urol. (2002) [Pubmed]
  7. Identification of an angiogenic mitogen selective for endocrine gland endothelium. LeCouter, J., Kowalski, J., Foster, J., Hass, P., Zhang, Z., Dillard-Telm, L., Frantz, G., Rangell, L., DeGuzman, L., Keller, G.A., Peale, F., Gurney, A., Hillan, K.J., Ferrara, N. Nature (2001) [Pubmed]
  8. Vascular endothelial growth factor is a secreted angiogenic mitogen. Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V., Ferrara, N. Science (1989) [Pubmed]
  9. Advanced glycation end products increase retinal vascular endothelial growth factor expression. Lu, M., Kuroki, M., Amano, S., Tolentino, M., Keough, K., Kim, I., Bucala, R., Adamis, A.P. J. Clin. Invest. (1998) [Pubmed]
  10. Vascular endothelial growth factor acts as a pericyte mitogen under hypoxic conditions. Yamagishi, S., Yonekura, H., Yamamoto, Y., Fujimori, H., Sakurai, S., Tanaka, N., Yamamoto, H. Lab. Invest. (1999) [Pubmed]
  11. Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy. Al-Shabrawey, M., Bartoli, M., El-Remessy, A.B., Platt, D.H., Matragoon, S., Behzadian, M.A., Caldwell, R.W., Caldwell, R.B. Am. J. Pathol. (2005) [Pubmed]
  12. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Takagi, H., King, G.L., Ferrara, N., Aiello, L.P. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  13. Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells. Suzuma, K., Takagi, H., Otani, A., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  14. Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells. Duval, M., Bédard-Goulet, S., Delisle, C., Gratton, J.P. J. Biol. Chem. (2003) [Pubmed]
  15. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. Suzuma, K., Naruse, K., Suzuma, I., Takahara, N., Ueki, K., Aiello, L.P., King, G.L. J. Biol. Chem. (2000) [Pubmed]
  16. Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. Mandriota, S.J., Menoud, P.A., Pepper, M.S. J. Biol. Chem. (1996) [Pubmed]
  17. Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-beta. Behzadian, M.A., Wang, X.L., Al-Shabrawey, M., Shabrawey, M., Caldwell, R.B. Glia (1998) [Pubmed]
  18. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Shih, S.C., Ju, M., Liu, N., Mo, J.R., Ney, J.J., Smith, L.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  19. Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. Chen, Y., Medhora, M., Falck, J.R., Pritchard, K.A., Jacobs, E.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  20. Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer. Neagoe, P.E., Lemieux, C., Sirois, M.G. J. Biol. Chem. (2005) [Pubmed]
  21. Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. Zhao, B., Cai, J., Boulton, M. Microvasc. Res. (2004) [Pubmed]
  22. Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex. Takahashi, S., Mendelsohn, M.E. J. Biol. Chem. (2003) [Pubmed]
  23. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro. Shen, B.Q., Lee, D.Y., Gerber, H.P., Keyt, B.A., Ferrara, N., Zioncheck, T.F. J. Biol. Chem. (1998) [Pubmed]
  24. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. Okamoto, N., Tobe, T., Hackett, S.F., Ozaki, H., Vinores, M.A., LaRochelle, W., Zack, D.J., Campochiaro, P.A. Am. J. Pathol. (1997) [Pubmed]
  25. Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells. Sone, H., Deo, B.K., Kumagai, A.K. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  26. Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Pepper, M.S., Vassalli, J.D., Orci, L., Montesano, R. Exp. Cell Res. (1993) [Pubmed]
  27. Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development. Greenaway, J., Gentry, P.A., Feige, J.J., LaMarre, J., Petrik, J.J. Biol. Reprod. (2005) [Pubmed]
  28. Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family. Tischer, E., Gospodarowicz, D., Mitchell, R., Silva, M., Schilling, J., Lau, K., Crisp, T., Fiddes, J.C., Abraham, J.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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