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Gene Review

Has1  -  hyaluronan synthase 1

Rattus norvegicus

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High impact information on Has1

  • We ectopically expressed three isoforms of hyaluronan synthase (HAS1, HAS2, or HAS3) in nontransformed rat 3Y1 cells and observed a de novo, massive formation of a hyaluronan matrix that resulted in a partial loss of contact-mediated inhibition of cell growth and migration [1].
  • Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity [2].
  • Here we report that activity and transcriptional levels of hyaluronan synthase (HAS) significantly increased after oncogenic malignant transformation of a rat 3Y1 fibroblast cell line [3].


  1. Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Itano, N., Atsumi, F., Sawai, T., Yamada, Y., Miyaishi, O., Senga, T., Hamaguchi, M., Kimata, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity. Rilla, K., Siiskonen, H., Spicer, A.P., Hyttinen, J.M., Tammi, M.I., Tammi, R.H. J. Biol. Chem. (2005) [Pubmed]
  3. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. Itano, N., Sawai, T., Atsumi, F., Miyaishi, O., Taniguchi, S., Kannagi, R., Hamaguchi, M., Kimata, K. J. Biol. Chem. (2004) [Pubmed]
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