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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rnf34  -  ring finger protein 34, E3 ubiquitin...

Rattus norvegicus

Synonyms: E3 ubiquitin-protein ligase RNF34, RING finger protein 34, RING finger protein MOMO
 
 
 
 
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High impact information on Rnf34

  • In vitro ubiquitination assay revealed that the combination of Momo and UbcH4 and H5c, or of Sakura and UbcH4, H5c and H6 is required for the reaction [1].
 

Biological context of Rnf34

  • In rat brain, we identified two novel Ub ligases, Momo and Sakura, carrying double zinc finger motif and RING finger domain [1].
  • Deletion mutagenesis suggested that the E3 Ub ligase activity of Momo and Sakura depended on their C-terminal domains containing RING finger structure, while their N-terminal domains influenced their membrane association [1].
 

Anatomical context of Rnf34

  • Momo expression is enriched in the brain gray matter and testis, and Sakura expression is more widely detected in the brain white matter as well as in many peripheral organs [1].

References

  1. A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes. Araki, K., Kawamura, M., Suzuki, T., Matsuda, N., Kanbe, D., Ishii, K., Ichikawa, T., Kumanishi, T., Chiba, T., Tanaka, K., Nawa, H. J. Neurochem. (2003) [Pubmed]
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