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Gene Review

BCL9L  -  B-cell CLL/lymphoma 9-like

Homo sapiens

Synonyms: B-cell CLL/lymphoma 9-like protein, B-cell lymphoma 9-like protein, BCL9-2, BCL9-like protein, DLNB11, ...
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Disease relevance of BCL9L


High impact information on BCL9L

  • Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription [2].
  • Here we examine the role of Tyrosine-142 phosphorylation in several assays and find that it is neither important for the recruitment of BCL9-2, nor for the transcriptional activity of beta-catenin in cultured mammalian cells, nor in Drosophila for Wg signaling activity in vivo [3].
  • FOXN5 gene, consisting of six exons, was linked to BCL9L gene at human chromosome 11q23 [4].
  • Human BCL9L and mouse Bcl9l genes were found to consist of eight exons [1].


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