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Gene Review:

BCL9L - B-cell CLL/lymphoma 9-like

Homo sapiens

Synonyms: B-cell CLL/lymphoma 9-like protein, B-cell lymphoma 9-like protein, BCL9-2, BCL9-like protein, DLNB11, ...

Hoffmans, R. et al., Katoh, M. et al., Harris, T.J. et al., Katoh, M. et al.

Katoh, Katoh,

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Disease relevance of BCL9L

Human BCL9L mRNA was expressed in fetal brain, adult lung, amygdala, eye, prostate, and also in several types of tumors including pancreatic cancer, prostate cancer, head and neck tumor and embryonal tumor [1].

High impact information on BCL9L

Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription [2].
Here we examine the role of Tyrosine-142 phosphorylation in several assays and find that it is neither important for the recruitment of BCL9-2, nor for the transcriptional activity of beta-catenin in cultured mammalian cells, nor in Drosophila for Wg signaling activity in vivo [3].
FOXN5 gene, consisting of six exons, was linked to BCL9L gene at human chromosome 11q23 [4].
Human BCL9L and mouse Bcl9l genes were found to consist of eight exons [1].

References

Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
Decisions, decisions: beta-catenin chooses between adhesion and transcription. Harris, T.J., Peifer, M. Trends Cell Biol. (2005) [Pubmed]
BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Hoffmans, R., Basler, K. Mech. Dev. (2007) [Pubmed]
Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]

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BCL9L	Bos taurus
BCL9L	Canis lupus familiaris
bcl9l	Danio rerio
BCL9L	Gallus gallus
Bcl9l	Mus musculus
BCL9L	Pan troglodytes
Bcl9l	Rattus norvegicus
bcl9l	Xenopus (Silurana) tropicalis

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