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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KSR2  -  kinase suppressor of ras 2

Homo sapiens

Synonyms: FLJ25965, Kinase suppressor of Ras 2, hKSR2
 
 
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High impact information on KSR2

  • Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling [1].
  • hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation [2].
  • Michaelis constants, maximum velocities, estradiol-17beta/testosterone (E(2)/T) activity ratios and inhibition patterns were consistent with a predominance of microsomal 17HSD/KSR2 and cytosolic 17HSD/KSR5, isoforms reactive with both E(2) and T, with evidence of estrogenic 17HSD/KSR1 in cytosol from some samples [3].

References

  1. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. Channavajhala, P.L., Wu, L., Cuozzo, J.W., Hall, J.P., Liu, W., Lin, L.L., Zhang, Y. J. Biol. Chem. (2003) [Pubmed]
  2. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. Channavajhala, P.L., Rao, V.R., Spaulding, V., Lin, L.L., Zhang, Y.G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms. Blomquist, C.H., Bonenfant, M., McGinley, D.M., Posalaky, Z., Lakatua, D.J., Tuli-Puri, S., Bealka, D.G., Tremblay, Y. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
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