Gene Review:
KSR1 - kinase suppressor of ras 1
Homo sapiens
Synonyms:
KSR, Kinase suppressor of Ras 1, RSU2
- Inflammatory bowel disease reveals the kinase activity of KSR1. Kolesnick, R., Xing, H.R. J. Clin. Invest. (2004)
- Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer. Xing, H.R., Cordon-Cardo, C., Deng, X., Tong, W., Campodonico, L., Fuks, Z., Kolesnick, R. Nat. Med. (2003)
- Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Lozano, J., Xing, R., Cai, Z., Jensen, H.L., Trempus, C., Mark, W., Cannon, R., Kolesnick, R. Cancer Res. (2003)
- KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. Bell, B., Xing, H., Yan, K., Gautam, N., Muslin, A.J. J. Biol. Chem. (1999)
- Male pseudohermaphroditism due to testicular 17-ketosteroid reductase deficiency. Schaison, G., Sitruk, L.R. Horm. Metab. Res. (1976)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Müller, J., Ory, S., Copeland, T., Piwnica-Worms, H., Morrison, D.K. Mol. Cell (2001)
- The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Kortum, R.L., Johnson, H.J., Costanzo, D.L., Volle, D.J., Razidlo, G.L., Fusello, A.M., Shaw, A.S., Lewis, R.E. Mol. Cell. Biol. (2006)
- Ras-Sensitive IMP Modulation of the Raf/MEK/ERK Cascade Through KSR1. Matheny, S.A., White, M.A. Meth. Enzymol. (2005)
- Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. Müller, J., Ritt, D.A., Copeland, T.D., Morrison, D.K. EMBO J. (2003)
- Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. Razidlo, G.L., Kortum, R.L., Haferbier, J.L., Lewis, R.E. J. Biol. Chem. (2004)
- Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras. Brennan, J.A., Volle, D.J., Chaika, O.V., Lewis, R.E. J. Biol. Chem. (2002)
- Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras. Xing, H.R., Lozano, J., Kolesnick, R. J. Biol. Chem. (2000)
- Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms. Blomquist, C.H., Bonenfant, M., McGinley, D.M., Posalaky, Z., Lakatua, D.J., Tuli-Puri, S., Bealka, D.G., Tremblay, Y. J. Steroid Biochem. Mol. Biol. (2002)
- The protein kinase KSR interacts with 14-3-3 protein and Raf. Xing, H., Kornfeld, K., Muslin, A.J. Curr. Biol. (1997)
- CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation. Ritt, D.A., Zhou, M., Conrads, T.P., Veenstra, T.D., Copeland, T.D., Morrison, D.K. Curr. Biol. (2007)
- Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Salerno, M., Palmieri, D., Bouadis, A., Halverson, D., Steeg, P.S. Mol. Cell. Biol. (2005)
- CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. Ziogas, A., Moelling, K., Radziwill, G. J. Biol. Chem. (2005)
- KSR Regulation of the Raf-MEK-ERK Cascade. Ritt, D.A., Daar, I.O., Morrison, D.K. Meth. Enzymol. (2005)
- Human leptospirosis in Erode, South India: serology, isolation, and characterization of the isolates by randomly amplified polymorphic DNA (RAPD) fingerprinting. Natarajaseenivasan, K., Prabhu, N., Selvanayaki, K., Raja, S.S., Ratnam, S. Jpn. J. Infect. Dis. (2004)