Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ZIK1 - zinc finger protein interacting with K...

Homo sapiens

Synonyms: ZNF762, Zinc finger protein 762, Zinc finger protein interacting with ribonucleoprotein K

Mihara, M. et al., Denisenko, O.N. et al.

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High impact information on ZIK1

When demethylation was induced in cell lines with their methylation by 5-aza-2'-deoxycytidine, expression of ZIK1, KAL1, and FGF14 was restored, supporting causal roles of methylation in their silencing [1].
ZIK1 methylation was present in glands isolated from physically distant positions within a stomach, showing that methylation occurred multifocally [1].
The deduced primary structure of one of the positive clones revealed a novel zinc finger protein, hereby denoted as Zik1 [2].

Biological context of ZIK1

Analysis of ZIK1 methylation in a single gland showed that the vast majority of DNA molecules isolated from a gland with IM were methylated and that those from a gland without IM were not [1].

References

Methylation of multiple genes in gastric glands with intestinal metaplasia: a disorder with polyclonal origins. Mihara, M., Yoshida, Y., Tsukamoto, T., Inada, K., Nakanishi, Y., Yagi, Y., Imai, K., Sugimura, T., Tatematsu, M., Ushijima, T. Am. J. Pathol. (2006) [Pubmed]
Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. Denisenko, O.N., O'Neill, B., Ostrowski, J., Van Seuningen, I., Bomsztyk, K. J. Biol. Chem. (1996) [Pubmed]

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