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Gene Review

MIR7-3HG  -  MIR7-3 host gene (non-protein coding)

Homo sapiens

Synonyms: C19orf30, Huh7, LINC00306, NCRNA00306, PGSF1, ...
 
 
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Disease relevance of C19orf30

  • CONCLUSIONS: Anti-human GH, anti-PGSF1a, and anti-PGSF2 antibodies were detected in patients with lymphocytic hypophysitis and other hypopituitarism, but were not detected in patients with non-functioning pituitary macroadenoma [1].
  • In our investigation of anti-PGSF1a antibody for pituitary diseases, we examined it in patients with RA and other autoimmune diseases [2].
 

High impact information on C19orf30

  • We unexpectedly discovered the frequent existence of anti-PGSF1a antibody in patients with RA [2].
  • OBJECTIVE: We recently identified a new protein, pituitary gland specific factor 1a (PGSF1a), that is specifically transcribed in the pituitary gland [2].
  • In addition to the eight known genes, we identified three novel pituitary-specific transcripts which encode putative proteins: pituitary gland specific factor 1a (PGSF1a), PGSF1b and PGSF2 [3].
 

Analytical, diagnostic and therapeutic context of C19orf30

References

  1. Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. Tanaka, S., Tatsumi, K.I., Kimura, M., Takano, T., Murakami, Y., Takao, T., Hashimoto, K., Kato, Y., Amino, N. Eur. J. Endocrinol. (2002) [Pubmed]
  2. Novel autoantibodies to pituitary gland specific factor 1a in patients with rheumatoid arthritis. Tanaka, S., Tatsumi, K., Tomita, T., Kimura, M., Takano, T., Yoshikawa, H., Amino, N. Rheumatology (Oxford, England) (2003) [Pubmed]
  3. Expression profile of active genes in the human pituitary gland. Tanaka, S., Tatsumi, K., Okubo, K., Itoh, K., Kawamoto, S., Matsubara, K., Amino, N. J. Mol. Endocrinol. (2002) [Pubmed]
 
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