The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hypopituitarism


Psychiatry related information on Hypopituitarism


High impact information on Hypopituitarism

  • Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia [7].
  • A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction [8].
  • Of the 24 who had apparently recovered from bites, 7 had clinical features of hypopituitarism and no response in plasma growth hormone or prolactin concentrations to symptom-producing insulin-induced hypoglycaemia [9].
  • Symptomless coeliac disease is therefore a commoner cause of short stature than is hypopituitarism; by use of the IFL-AGA test it is possible to select patients for biopsy, thereby identifying most of the coeliac patients [10].
  • Clonidine induced a slight increase in blood glucose in healthy subjects and a slight decrease in patients with hypopituitarism [11].

Chemical compound and disease context of Hypopituitarism


Biological context of Hypopituitarism


Anatomical context of Hypopituitarism


Gene context of Hypopituitarism

  • Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism [16].
  • However, controversy exists about the timing and extent of pituitary insufficiency, and it remains unclear whether adrenal failure is a typical feature of this condition.We performed a retrospective longitudinal analysis of nine patients with PROP1 mutations who were under medical supervision at our clinic for 15.7 +/- 3.4 yr [26].
  • Thus, we hypothesized that mutations in one or both of the two human LHX3 isoforms are responsible for posterior pituitary ectopia associated with anterior pituitary hypopituitarism [27].
  • GH and somatomedin-C response to acute hpGRF-44 iv administration (1 microgram/Kg bw) was studied in 16 patients with hypopituitarism (GHD) and in 7 constitutionally short subjects [28].
  • Moreover, linkage analysis of AHT137 revealed no co-segregation between the PROP1 locus and the CPHD phenotype, excluding this gene as candidate for canine CPHD and providing a new spontaneous model of hypopituitarism [29].

Analytical, diagnostic and therapeutic context of Hypopituitarism


  1. Hyponatremia and inappropriate secretion of vasopressin (antidiuretic hormone) in patients with hypopituitarism. Oelkers, W. N. Engl. J. Med. (1989) [Pubmed]
  2. Immunoreactive corticotropin-releasing factor in human plasma. Suda, T., Tomori, N., Yajima, F., Sumitomo, T., Nakagami, Y., Ushiyama, T., Demura, H., Shizume, K. J. Clin. Invest. (1985) [Pubmed]
  3. Hypophysiotropic hormone testing in a patient with hypothalamic hypopituitarism. Feldman, A., Bloomgarden, Z.T. Am. J. Med. (1986) [Pubmed]
  4. Demonstration of insulin-like growth factor I in human urine. Hizuka, N., Takano, K., Tanaka, I., Asakawa, K., Miyakawa, M., Horikawa, R., Shizume, K. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  5. Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. Rose, S.R., Lustig, R.H., Pitukcheewanont, P., Broome, D.C., Burghen, G.A., Li, H., Hudson, M.M., Kun, L.E., Heideman, R.L. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  6. SOX3 is required during the formation of the hypothalamo-pituitary axis. Rizzoti, K., Brunelli, S., Carmignac, D., Thomas, P.Q., Robinson, I.C., Lovell-Badge, R. Nat. Genet. (2004) [Pubmed]
  7. Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Pfäffle, R.W., DiMattia, G.E., Parks, J.S., Brown, M.R., Wit, J.M., Jansen, M., Van der Nat, H., Van den Brande, J.L., Rosenfeld, M.G., Ingraham, H.A. Science (1992) [Pubmed]
  8. A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction. Carvalho, L.R., Woods, K.S., Mendonca, B.B., Marcal, N., Zamparini, A.L., Stifani, S., Brickman, J.M., Arnhold, I.J., Dattani, M.T. J. Clin. Invest. (2003) [Pubmed]
  9. Acute and chronic pituitary failure resembling Sheehan's syndrome following bites by Russell's viper in Burma. Tun-Pe, n.u.l.l., Phillips, R.E., Warrell, D.A., Moore, R.A., Tin-Nu-Swe, n.u.l.l., Myint-Lwin, n.u.l.l., Burke, C.W. Lancet (1987) [Pubmed]
  10. Can antigliadin antibody detect symptomless coeliac disease in children with short stature? Cacciari, E., Salardi, S., Volta, U., Biasco, G., Lazzari, R., Corazza, G.R., Feliciani, M., Cicognani, A., Partesotti, S., Azzaroni, D. Lancet (1985) [Pubmed]
  11. Oral clonidine as a growth hormone stimulation test. Gil-Ad, I., Topper, E., Laron, Z. Lancet (1979) [Pubmed]
  12. Hypothalamic insufficiency: the cause of hypopituitarism in sarcoidosis. Stuart, C.A., Neelon, F.A., Lebovitz, H.E. Ann. Intern. Med. (1978) [Pubmed]
  13. Hypothalamic-hypopituitarism due to temporal arteritis. Everett, G.D., Amatruda, J.M., Woolf, P.D. Arch. Intern. Med. (1979) [Pubmed]
  14. Hypothalamic hypopituitarism after pituitary apoplexy in acromegaly. Lawrence, A.M., Gordon, D.L., Hagen, T.C., Schwartz, M.A. Arch. Intern. Med. (1977) [Pubmed]
  15. Electroconvulsive therapy for iatrogenic hypothalamic-hypopituitarism (CRF-ACTH type). Pitts, F.N., Patterson, C.W. The American journal of psychiatry. (1979) [Pubmed]
  16. Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. Woods, K.S., Cundall, M., Turton, J., Rizotti, K., Mehta, A., Palmer, R., Wong, J., Chong, W.K., Al-Zyoud, M., El-Ali, M., Otonkoski, T., Martinez-Barbera, J.P., Thomas, P.Q., Robinson, I.C., Lovell-Badge, R., Woodward, K.J., Dattani, M.T. Am. J. Hum. Genet. (2005) [Pubmed]
  17. Neurohypophyseal function in postpartum hypopituitarism: impaired plasma vasopressin response to osmotic stimuli. Iwasaki, Y., Oiso, Y., Yamauchi, K., Takatsuki, K., Kondo, K., Hasegawa, H., Itatsu, T., Niinomi, M., Tomita, A. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  18. Effects of 7 years of growth hormone replacement therapy in hypopituitary adults. Chrisoulidou, A., Beshyah, S.A., Rutherford, O., Spinks, T.J., Mayet, J., Kyd, P., Anyaoku, V., Haida, A., Ariff, B., Murphy, M., Thomas, E., Robinson, S., Foale, R., Johnston, D.G. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  19. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. Miller, K.K., Biller, B.M., Beauregard, C., Lipman, J.G., Jones, J., Schoenfeld, D., Sherman, J.C., Swearingen, B., Loeffler, J., Klibanski, A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  20. Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy. Golgeli, A., Tanriverdi, F., Suer, C., Gokce, C., Ozesmi, C., Bayram, F., Kelestimur, F. Eur. J. Endocrinol. (2004) [Pubmed]
  21. Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors. Bülow, B., Hagmar, L., Eskilsson, J., Erfurth, E.M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  22. Immunoreactive corticotropin-releasing factor concentrations in cerebrospinal fluid from patients with hypothalamic-pituitary-adrenal disorders. Tomori, N., Suda, T., Tozawa, F., Demura, H., Shizume, K., Mouri, T. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  23. Multiple congenital malformations in two sibs reminiscent of hydrolethalus and pseudotrisomy 13 syndromes. Dincsoy, M.Y., Salih, M.A., al-Jurayyan, N., al Saadi, M., Patel, P.J. Am. J. Med. Genet. (1995) [Pubmed]
  24. Investigation and outcome of neonatal hepatitis in infants with hypopituitarism. Spray, C.H., Mckiernan, P., Waldron, K.E., Shaw, N., Kirk, J., Kelly, D.A. Acta Paediatr. (2000) [Pubmed]
  25. Coronary bypass surgery in patients with Sheehan's syndrome. Syed, A.U., Al Fagih, M.R., Fouda, M. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2001) [Pubmed]
  26. PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis. Böttner, A., Keller, E., Kratzsch, J., Stobbe, H., Weigel, J.F., Keller, A., Hirsch, W., Kiess, W., Blum, W.F., Pfäffle, R.W. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  27. Molecular analysis of LHX3 and PROP-1 in pituitary hormone deficiency patients with posterior pituitary ectopia. Sloop, K.W., Walvoord, E.C., Showalter, A.D., Pescovitz, O.H., Rhodes, S.J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  28. Growth hormone and somatomedin-C response to synthetic human pancreatic tumor GH-releasing factor in hypopituitary and constitutionally short children. Minuto, F., Barreca, A., Del Monte, P., Mauri, R., Resentini, M., Fortini, P., Morabito, M., Giordano, G. J. Endocrinol. Invest. (1986) [Pubmed]
  29. Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. Lantinga-van Leeuwen, I.S., Kooistra, H.S., Mol, J.A., Renier, C., Breen, M., van Oost, B.A. Cytogenet. Cell Genet. (2000) [Pubmed]
  30. Growth hormone (GH) provocative retesting of 108 young adults with childhood-onset GH deficiency and the diagnostic value of insulin-like growth factor I (IGF-I) and IGF-binding protein-3. Juul, A., Kastrup, K.W., Pedersen, S.A., Skakkebaek, N.E. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  31. Urinary growth hormone (GH) measurements are useful for evaluating endogenous GH secretion. Sukegawa, I., Hizuka, N., Takano, K., Asakawa, K., Horikawa, R., Hashida, S., Ishikawa, E., Mohri, Z., Murakami, Y., Shizume, K. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  32. External radiotherapy of pituitary adenomas. Zierhut, D., Flentje, M., Adolph, J., Erdmann, J., Raue, F., Wannenmacher, M. Int. J. Radiat. Oncol. Biol. Phys. (1995) [Pubmed]
  33. Inappropriate secretion of antidiuretic hormone in Sheehan's syndrome: a rare cause of postpartum hyponatremia. Putterman, C., Almog, Y., Caraco, Y., Gross, D.J., Ben-Chetrit, E. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  34. The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism. Isidori, A.M., Kaltsas, G.A., Perry, L., Burrin, J.M., Besser, G.M., Monson, J.P. Clin. Endocrinol. (Oxf) (2003) [Pubmed]
WikiGenes - Universities