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Gene Review

LPAR4  -  lysophosphatidic acid receptor 4

Homo sapiens

Synonyms: G-protein coupled receptor 23, GPR23, LPA receptor 4, LPA-4, LPA4, ...
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High impact information on GPR23

  • Sequence analyses of human GPR92 and its mouse homolog have approximately 35% amino acid identity with LPA4/GPR23 [1].
  • We identified an orphan G protein-coupled receptor, p2y9/GPR23, as the fourth LPA receptor (LPA4) [2].
  • Competition binding and reporter gene assays showed that p2y9/GPR23 preferred structural analogs of LPA with a rank order of 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA [2].
  • Starting from this partial sequence, we have isolated a complete clone and identified a 1113 base pair open reading frame encoding a new G-coupled receptor that we have called P2Y5-like [3].

Analytical, diagnostic and therapeutic context of GPR23

  • Quantitative real-time PCR demonstrated that mRNA of p2y9/GPR23 was significantly abundant in ovary compared with other tissues [2].
  • A construct encoding this P2Y5-like receptor was transfected into COS-7, 1321N1, and CHO-K1 cells, and expression was documented by Northern blotting [3].


  1. GPR92 as a new G(12/13)- and G(q)-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. Lee, C.W., Rivera, R., Gardell, S., Dubin, A.E., Chun, J. J. Biol. Chem. (2006) [Pubmed]
  2. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. Noguchi, K., Ishii, S., Shimizu, T. J. Biol. Chem. (2003) [Pubmed]
  3. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. Janssens, R., Boeynaems, J.M., Godart, M., Communi, D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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