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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IGHJ6  -  immunoglobulin heavy joining 6

Homo sapiens

 
 
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High impact information on IGHJ6

  • These cases used the IGHJ6 gene; 4 of 7 were unmutated; 6 of 7 carried the V(lambda)2-14 (IGLV3-21) light-chain gene with a similar LCDR3 [1].
  • In order to facilitate molecular analysis of antibody responses in Rhesus monkeys ( Macaca mulatta), we used PCR techniques to clone and sequence the germline IGHD gene repertoire and the IGHD7- IGHJ6 locus in its entirety [2].
  • For example, within the IGHJ group, IGHJ3 has average removals of 1.3 nucleotides compared to 6.4 nucleotides for IGHJ6 genes (p < 0.002) [3].

References

  1. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Ghia, P., Stamatopoulos, K., Belessi, C., Moreno, C., Stella, S., Guida, G., Michel, A., Crespo, M., Laoutaris, N., Montserrat, E., Anagnostopoulos, A., Dighiero, G., Fassas, A., Caligaris-Cappio, F., Davi, F. Blood (2005) [Pubmed]
  2. The Rhesus monkey immunoglobulin IGHD and IGHJ germline repertoire. Link, J.M., Hellinger, M.A., Schroeder, H.W. Immunogenetics (2002) [Pubmed]
  3. Exonuclease activity and P nucleotide addition in the generation of the expressed immunoglobulin repertoire. Jackson, K.J., Gaeta, B., Sewell, W., Collins, A.M. BMC Immunol. (2004) [Pubmed]
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