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Gene Review

GPR26  -  G protein-coupled receptor 26

Homo sapiens

Synonyms: G-protein coupled receptor 26
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High impact information on GPR26

  • GPR78 shared highest identity with the oGPCR gene GPR26 (56% identity in the transmembrane (TM) regions). psi GPR79 shared highest sequence identity with the P2Y(2) gene and contained a frame-shift truncating the encoded receptor in TM5, demonstrating a pseudogene [1].
  • A human genomic DNA fragment encoding a partial open reading frame (ORF) and a rat cDNA encoding the full length ORF of GPR26 were obtained by library screening [2].
  • The rat GPR26 cDNA encoded a protein of 317 amino acids, most similar (albeit distantly related) to the serotonin 5-HT(5A) and gastrin releasing hormone BB2 receptors [2].
  • HEK293 and Rh7777 cells transfected with GPR26 cDNA displayed high basal cAMP levels, slow growth rate of clonal populations and derangements of normal cell shape [2].
  • A search of the expressed sequence tag (EST) database retrieved a human cDNA sequence which partially encoded a novel G protein-coupled receptor (GPCR) GPR26 [2].


  1. Discovery and mapping of ten novel G protein-coupled receptor genes. Lee, D.K., Nguyen, T., Lynch, K.R., Cheng, R., Vanti, W.B., Arkhitko, O., Lewis, T., Evans, J.F., George, S.R., O'Dowd, B.F. Gene (2001) [Pubmed]
  2. Cloning and characterization of additional members of the G protein-coupled receptor family. Lee, D.K., Lynch, K.R., Nguyen, T., Im, D.S., Cheng, R., Saldivia, V.R., Liu, Y., Liu, I.S., Heng, H.H., Seeman, P., George, S.R., O'Dowd, B.F., Marchese, A. Biochim. Biophys. Acta (2000) [Pubmed]
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