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Gene Review:

pbp2 - penicillin-binding protein 2

Staphylococcus aureus subsp. aureus MRSA252

Severin, A. et al., Łeski, T.A. et al.

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Disease relevance of pbp2

Ceftizoxime, a beta-lactam antibiotic with high selective affinity for penicillin-binding protein 2 (PBP2) of Staphylococcus aureus, was used to select a spontaneous resistant mutant of S. aureus strain 27s [1].

High impact information on pbp2

The key penicillin binding protein essential for vancomycin resistance and for the synthesis of the abnormally structured cell walls characteristic of vancomycin-resistant S. aureus (A. Severin, K. Tabei, F. Tenover, M. Chung, N. Clarke, and A. Tomasz, J. Biol. Chem. 279:3398-3407, 2004) is penicillin binding protein 2 [2].

References

Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. Łeski, T.A., Tomasz, A. J. Bacteriol. (2005) [Pubmed]
Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex. Severin, A., Wu, S.W., Tabei, K., Tomasz, A. Antimicrob. Agents Chemother. (2004) [Pubmed]

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