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MeSH Review

Vancomycin Resistance

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Disease relevance of Vancomycin Resistance


High impact information on Vancomycin Resistance


Chemical compound and disease context of Vancomycin Resistance


Biological context of Vancomycin Resistance


Anatomical context of Vancomycin Resistance


Associations of Vancomycin Resistance with chemical compounds

  • Whereas major advances have been made in our understanding of methicillin and vancomycin resistance mechanisms, we still need to identify the sources and reservoirs of the genetic determinants of resistance and to discover how they disseminate in the environment [24].
  • Antibiotic resistances among the infections included high-level gentamicin resistance (26%), ampicillin resistance (10%), and vancomycin resistance (8%) [25].
  • These combined observations reflect the relationship which seems to exist between the new D-lactate peptidoglycan precursor, synthesized when the vancomycin resistance is expressed, and the affinity of the different PBPs for this precursor [26].
  • In terms of resistance (highest concentration of antibiotic permitting growth), the levels of vancomycin resistance of six strains ranged from 0.2 to 1.0 microgram/ml, and the level of erythromycin resistance of these strains was 0.02 or 0.05 micrograms/ml [27].
  • The results indicate that mecA--the genetic determinant of oxacillin resistance--while essential for oxacillin resistance, is not involved with the expression of vancomycin resistance [28].

Gene context of Vancomycin Resistance


Analytical, diagnostic and therapeutic context of Vancomycin Resistance


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  10. Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions. Haldimann, A., Prahalad, M.K., Fisher, S.L., Kim, S.K., Walsh, C.T., Wanner, B.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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  13. Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains. Hanrahan, J., Hoyen, C., Rice, L.B. Antimicrob. Agents Chemother. (2000) [Pubmed]
  14. Rapid detection of vancomycin-resistant enterococci. Edberg, S.C., Hardalo, C.J., Kontnick, C., Campbell, S. J. Clin. Microbiol. (1994) [Pubmed]
  15. Impact of sigB mutation on Staphylococcus aureus oxacillin and vancomycin resistance varies with parental background and method of assessment. Singh, V.K., Schmidt, J.L., Jayaswal, R.K., Wilkinson, B.J. Int. J. Antimicrob. Agents (2003) [Pubmed]
  16. Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Arthur, M., Depardieu, F., Snaith, H.A., Reynolds, P.E., Courvalin, P. Antimicrob. Agents Chemother. (1994) [Pubmed]
  17. Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis. McKessar, S.J., Berry, A.M., Bell, J.M., Turnidge, J.D., Paton, J.C. Antimicrob. Agents Chemother. (2000) [Pubmed]
  18. Comparison of Tn1546-like elements in vancomycin-resistant Staphylococcus aureus isolates from Michigan and Pennsylvania. Clark, N.C., Weigel, L.M., Patel, J.B., Tenover, F.C. Antimicrob. Agents Chemother. (2005) [Pubmed]
  19. In vivo emergence of subpopulations expressing teicoplanin or vancomycin resistance phenotypes in a glycopeptide-susceptible, methicillin-resistant strain of Staphylococcus aureus. Vaudaux, P., Francois, P., Berger-Bächi, B., Lew, D.P. J. Antimicrob. Chemother. (2001) [Pubmed]
  20. High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan. Lu, J.J., Perng, C.L., Ho, M.F., Chiueh, T.S., Lee, W.H. J. Clin. Microbiol. (2001) [Pubmed]
  21. Staphylococcus heterogeneously resistant to vancomycin in China and antimicrobial activities of imipenem and vancomycin in combination against it. Benquan, W., Yingchun, T., Kouxing, Z., Tiantuo, Z., Jiaxing, Z., Shuqing, T. J. Clin. Microbiol. (2002) [Pubmed]
  22. In-vitro synergy and mechanism of interaction between vancomycin and ciprofloxacin against enterococcal isolates. Unal, S., Flokowitsch, J., Mullen, D.L., Preston, D.A., Nicas, T.I. J. Antimicrob. Chemother. (1993) [Pubmed]
  23. Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides. Kuzin, A.P., Sun, T., Jorczak-Baillass, J., Healy, V.L., Walsh, C.T., Knox, J.R. Structure (2000) [Pubmed]
  24. Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: therapeutic realities and possibilities. Michel, M., Gutmann, L. Lancet (1997) [Pubmed]
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  26. Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium. Gutmann, L., al-Obeid, S., Billot-Klein, D., Guerrier, M.L., Collatz, E. Antimicrob. Agents Chemother. (1994) [Pubmed]
  27. Vancomycin hypersusceptibility in Neisseria gonorrhoeae isolated from patients involves diverse mutations. Koelbl, J.A., Catlin, B.W. Antimicrob. Agents Chemother. (1986) [Pubmed]
  28. Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex. Severin, A., Wu, S.W., Tabei, K., Tomasz, A. Antimicrob. Agents Chemother. (2004) [Pubmed]
  29. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Paulsen, I.T., Banerjei, L., Myers, G.S., Nelson, K.E., Seshadri, R., Read, T.D., Fouts, D.E., Eisen, J.A., Gill, S.R., Heidelberg, J.F., Tettelin, H., Dodson, R.J., Umayam, L., Brinkac, L., Beanan, M., Daugherty, S., DeBoy, R.T., Durkin, S., Kolonay, J., Madupu, R., Nelson, W., Vamathevan, J., Tran, B., Upton, J., Hansen, T., Shetty, J., Khouri, H., Utterback, T., Radune, D., Ketchum, K.A., Dougherty, B.A., Fraser, C.M. Science (2003) [Pubmed]
  30. The emergence of Staphylococcus aureus with reduced susceptibility to vancomycin in Japan. Hiramatsu, K. Am. J. Med. (1998) [Pubmed]
  31. Silencing of glycopeptide resistance in Enterococcus faecalis BM4405 by novobiocin. Patiño, L.A., Chippaux, M., Courvalin, P., Périchon, B. Antimicrob. Agents Chemother. (2005) [Pubmed]
  32. tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus. Maki, H., McCallum, N., Bischoff, M., Wada, A., Berger-Bächi, B. Antimicrob. Agents Chemother. (2004) [Pubmed]
  33. Screening for enterocins and detection of hemolysin and vancomycin resistance in enterococci of different origins. De Vuyst, L., Foulquié Moreno, M.R., Revets, H. Int. J. Food Microbiol. (2003) [Pubmed]
  34. Characterization of a highly glycopeptide-resistant Enterococcus gallinarum isolate. Lu, J.J., Wu, J.C., Chiueh, T.S., Perng, C.L., Chi, W.M., Lee, W.H. J. Formos. Med. Assoc. (2000) [Pubmed]
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