Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TRAV9-1 - T cell receptor alpha variable 9-1

Homo sapiens

Synonyms: TCRAV9S1, TRAV91

Zhao, Y. et al., Haynes, M.R. et al.

Haynes, Wu,

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Disease relevance of TRAV9-1

A retroviral vector expressing both TRAV9-1 and TRBV20-1 was constructed and used for transduction of OKT3-stimulated peripheral blood lymphocytes from melanoma patients [1].

High impact information on TRAV9-1

Two TRAV/DV pseudogenes were discovered bearing 80 and 65% sequence similarity to TRAV14DV4 and TRAV9-1/9-2 genes, respectively [2].
Antibody blocking experiments confirmed that the specificity of TRAV9-1/TRBV20-1 mRNA-transfected T cells were CD4 dependent and HLA-DP4 restricted [1].

Analytical, diagnostic and therapeutic context of TRAV9-1

By screening different combination of the alpha/beta chains using RNA electroporation, TRAV9-1 (Valpha22.1) and TRBV20-1 (Vbeta2) were found to be the functional pair in line SG6 [1].

References

Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes. Zhao, Y., Zheng, Z., Khong, H.T., Rosenberg, S.A., Morgan, R.A. J. Immunother. (2006) [Pubmed]
Gene discovery at the human T-cell receptor alpha/delta locus. Haynes, M.R., Wu, G.E. Immunogenetics (2007) [Pubmed]

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