The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

TRBV20-1  -  T cell receptor beta variable 20-1

Homo sapiens

Synonyms: TCRBV20S1, TCRBV2S1, TRBV201
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TRBV20-1

 

High impact information on TRBV20-1

  • Allelic polymorphism of the T cell receptor variable segment, TCRBV2S1, does not influence susceptibility to RA [4].
  • The TCRBV2S1 allele, genotype and inferred phenotype frequencies were similar in the RA patients and controls [4].
  • RESULTS--The SSCP typing method detected two previously unknown alleles of the TCRBV2S1 gene segment [4].
  • TCRBV20S1 allele frequencies vary among human populations [5].
  • Antibody blocking experiments confirmed that the specificity of TRAV9-1/TRBV20-1 mRNA-transfected T cells were CD4 dependent and HLA-DP4 restricted [1].
 

Analytical, diagnostic and therapeutic context of TRBV20-1

  • By screening different combination of the alpha/beta chains using RNA electroporation, TRAV9-1 (Valpha22.1) and TRBV20-1 (Vbeta2) were found to be the functional pair in line SG6 [1].
  • The level of TCRBV2S1 expression in the multiplex families was significantly higher than all the control groups for both the CD4+ and CD8+ T lymphocyte subsets [2].

References

  1. Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes. Zhao, Y., Zheng, Z., Khong, H.T., Rosenberg, S.A., Morgan, R.A. J. Immunother. (2006) [Pubmed]
  2. Individuals from multiplex insulin-dependent diabetes mellitus (IDDM) families express higher levels of TCRBV2S1 than controls. Craddock, T., Shefta, J., Gilbey, S.G., Lancaster, F.C., Boylston, A.W. Hum. Immunol. (1998) [Pubmed]
  3. A subset of Sjögren's syndrome associates with the TCRBV13S2 locus but not the TCRBV2S1 locus. Kay, R.A., Hutchings, C.J., Ollier, W.E. Hum. Immunol. (1995) [Pubmed]
  4. Analysis of a T-cell receptor V beta segment implicated in susceptibility to rheumatoid arthritis: V beta 2 germline polymorphism does not encode susceptibility. Pile, K., Wordsworth, P., Lioté, F., Bardin, T., Bell, J., Cornélis, F. Ann. Rheum. Dis. (1993) [Pubmed]
  5. TCRBV20S1 allele frequencies vary among human populations. Barron, K.S., Deulofeut, H., Robinson, M.A. Immunogenetics (1995) [Pubmed]
 
WikiGenes - Universities