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Gene Review

catD  -  3-oxoadipate enol-lactonase

Acinetobacter sp. ADP1

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Disease relevance of catD

  • Acquisition of apparent DNA slippage structures during extensive evolutionary divergence of pcaD and catD genes encoding identical catalytic activities in Acinetobacter calcoaceticus [1].

High impact information on catD

  • Sequence repetitions within pcaD suggest that the multiple mutations required for its extensive divergence from catD were achieved in part by acquisition of a complex DNA slippage structure [1].
  • Two ORFs located immediately downstream catD were most similar with two ORFs in cat gene cluster of Acinetobacter calcoaceticus ADP1 but the gene structure of catR1B1C1A1 was closest to that found in Frateurua sp. ANA-18 or Pseudomonas putida PRS2000 [2].

Biological context of catD

  • In the 56% of the genes where selection for identical aa residues was not imposed, pcaD and catD have diverged so extensively that nt sequence identity of the aligned segments is only 28.2%; the G+C contents of these segments from the respective genes differ by 8% [1].


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