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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GRID2  -  glutamate receptor, ionotropic, delta 2

Homo sapiens

Synonyms: GLURD2, GluD2, GluR delta-2 subunit, GluR-delta-2, Glutamate receptor ionotropic, delta-2
 
 
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High impact information on GRID2

  • Here we study a mouse locus containing the ionotropic glutamate receptor delta 2 (grid2) gene in which spontaneous chromosome rearrangements occur frequently, giving rise to mutant animals in inbred populations [1].
  • We identify and clone common fragile sites overlapping the mouse grid2 gene and its human ortholog GRID2, lying respectively at bands 6C1 and 4q22 in a 7-Mb-long region of synteny [1].
  • We isolated the human glutamate receptor delta 2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor delta 2 (Grid2) gene [2].
  • Thus, the mapping of the GRID2 gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes [2].
 

Biological context of GRID2

References

  1. Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer. Rozier, L., El-Achkar, E., Apiou, F., Debatisse, M. Oncogene (2004) [Pubmed]
  2. The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22. Hu, W., Zuo, J., De Jager, P.L., Heintz, N. Genomics (1998) [Pubmed]
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