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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Synteny


High impact information on Synteny


Chemical compound and disease context of Synteny

  • As to linkage relationships of C3 with marker systems and with myotonic dystrophy, there was evidence (most of it first presented at the 6th International Congress of Human Genetics, Jerusalem 1981) for synteny with ABH secretion (Se): C3-Se (males) z = 4.35, theta = 0.12 and with Lewis secretion (LES): C3-LES (males z = 3.63, theta = 0.04) [11].

Biological context of Synteny


Anatomical context of Synteny


Associations of Synteny with chemical compounds


Gene context of Synteny

  • We have combined physical mapping of the human locus with meiotic and physical mapping in the mouse, together with synteny homologies between the two species, to compare the physical relationship between MYOD1 and the genetically ascertained human rhabdomyosarcoma-associated locus [25].
  • The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs [26].
  • Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny [27].
  • The conserved synteny of the MC2R, MC5R, and MC4R cluster in chicken (GGA2), human (HSA18), and other mammals suggests that this cluster is ancient and was formed by local gene duplications that most likely occurred early in vertebrate evolution [28].
  • Since the human gene was mapped previously to chromosome 2q14, the location of Bin1 defines a previously unrecognized region of synteny between human chromosome 2 and mouse chromosome 18 [29].

Analytical, diagnostic and therapeutic context of Synteny


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  3. The physical and genetic map surrounding the Lyst gene on mouse chromosome 13. Misumi, D.J., Nagle, D.L., McGrail, S.H., Dussault, B.J., Smutko, J.S., Chen, H., Charlat, O., Duyk, G.M., Ebeling, C., Baldini, L., Carlson, G.A., Moore, K.J. Genomics (1997) [Pubmed]
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  10. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Lane, T.F., Deng, C., Elson, A., Lyu, M.S., Kozak, C.A., Leder, P. Genes Dev. (1995) [Pubmed]
  11. Genetics and linkage relationships of the C3 polymorphism: discovery of C3-Se linkage and assignment of LES-C3-DM-Se-PEPD-Lu synteny to chromosome 19. Eiberg, H., Mohr, J., Nielsen, L.S., Simonsen, N. Clin. Genet. (1983) [Pubmed]
  12. Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16. Dietrich, W.F., Radany, E.H., Smith, J.S., Bishop, J.M., Hanahan, D., Lander, E.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  13. A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. Lehman, A.L., Nakatsu, Y., Ching, A., Bronson, R.T., Oakey, R.J., Keiper-Hrynko, N., Finger, J.N., Durham-Pierre, D., Horton, D.B., Newton, J.M., Lyon, M.F., Brilliant, M.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Flint, J., Tufarelli, C., Peden, J., Clark, K., Daniels, R.J., Hardison, R., Miller, W., Philipsen, S., Tan-Un, K.C., McMorrow, T., Frampton, J., Alter, B.P., Frischauf, A.M., Higgs, D.R. Hum. Mol. Genet. (2001) [Pubmed]
  15. Human PEG1/MEST, an imprinted gene on chromosome 7. Kobayashi, S., Kohda, T., Miyoshi, N., Kuroiwa, Y., Aisaka, K., Tsutsumi, O., Kaneko-Ishino, T., Ishino, F. Hum. Mol. Genet. (1997) [Pubmed]
  16. Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. Davidson, A.J., Postlethwait, J.H., Yan, Y.L., Beier, D.R., van Doren, C., Foernzler, D., Celeste, A.J., Crosier, K.E., Crosier, P.S. Genome Res. (1999) [Pubmed]
  17. Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11----q21 segment of chromosome 6. Harbitz, I., Chowdhary, B., Thomsen, P.D., Davies, W., Kaufmann, U., Kran, S., Gustavsson, I., Christensen, K., Hauge, J.G. Genomics (1990) [Pubmed]
  18. Identification and characterization of the rat homologue of LAIR-1. Lebbink, R.J., de Ruiter, T., Kaptijn, G.J., Meyaard, L. Immunogenetics (2005) [Pubmed]
  19. Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15. Kaiser, P., Mariani, P. Immunogenetics (1999) [Pubmed]
  20. Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble). Moore, E.E., Jones, C., Kao, F.T., Oates, D.C. Am. J. Hum. Genet. (1977) [Pubmed]
  21. Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Luo, H., Chaudhuri, A., Zbrzezna, V., He, Y., Pogo, A.O. Mol. Cell. Biol. (2000) [Pubmed]
  22. Assignment of a gene for human mitochondrial isocitrate dehydrogenase (ICD-M, EC to chromosome 15. Grzeschik, K.H. Hum. Genet. (1976) [Pubmed]
  23. Mendel, linkage, and synteny. Novitski, E., Blixt, S. Bioscience. (1978) [Pubmed]
  24. The Medicago truncatula SUNN gene encodes a CLV1-like leucine-rich repeat receptor kinase that regulates nodule number and root length. Schnabel, E., Journet, E.P., de Carvalho-Niebel, F., Duc, G., Frugoli, J. Plant Mol. Biol. (2005) [Pubmed]
  25. Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11. Scrable, H.J., Johnson, D.K., Rinchik, E.M., Cavenee, W.K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  26. The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. Klovins, J., Haitina, T., Fridmanis, D., Kilianova, Z., Kapa, I., Fredriksson, R., Gallo-Payet, N., Schiöth, H.B. Mol. Biol. Evol. (2004) [Pubmed]
  27. Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny. Santagati, F., Abe, K., Schmidt, V., Schmitt-John, T., Suzuki, M., Yamamura, K., Imai, K. Genetics (2003) [Pubmed]
  28. Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates. Schiöth, H.B., Raudsepp, T., Ringholm, A., Fredriksson, R., Takeuchi, S., Larhammar, D., Chowdhary, B.P. Genomics (2003) [Pubmed]
  29. The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2. Mao, N.C., Steingrimsson, E., DuHadaway, J., Wasserman, W., Ruiz, J.C., Copeland, N.G., Jenkins, N.A., Prendergast, G.C. Genomics (1999) [Pubmed]
  30. Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7. Davidson, H., Taylor, M.S., Doherty, A., Boyd, A.C., Porteous, D.J. Genome Res. (2000) [Pubmed]
  31. Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). Wang, W., Zhang, Q., Acland, G.M., Mellersh, C., Ostrander, E.A., Ray, K., Aguirre, G.D. Gene (1999) [Pubmed]
  32. Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome. Yamaguchi, F., Yamaguchi, K., Tokuda, M., Brenner, S. FEBS Lett. (1999) [Pubmed]
  33. Brief communication: comparative mapping of the human estrogen receptor (ESR) and the Kallmann (KAL) regions to the chromosomes of the great apes. Samonte, R.V., Conte, R.A., Verma, R.S. Am. J. Phys. Anthropol. (1997) [Pubmed]
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