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Nqo2  -  NAD(P)H dehydrogenase, quinone 2

Rattus norvegicus

Synonyms: NRH:quinone oxidoreductase 2, QR2, Quinone reductase 2
 
 
 
 
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High impact information on Nqo2

  • In the present work, we showed that the binding of melatonin at MT3/QR2 was better described with 2-[125I]-iodomethoxy-carbonylamino-N-acetyltryptamine (2-[125I]-I-MCA-NAT) and, most importantly, that it was measurable at 20 degrees while it has been initially described and thoroughly studied using 2-[125I]-iodomelatonin at 4 degrees [1].
  • The third binding site of melatonin, MT3, has been recently characterized as a melatonin-sensitive form of the quinone reductase 2 (QR2, EC 1.6.99.2) [1].
 

Biological context of Nqo2

  • In addition, we further document the MT3/QR2 binding site by demonstrating that it was widely distributed among mammals, although inter-species and inter-tissues differences exist [1].

References

  1. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 . Nosjean, O., Nicolas, J.P., Klupsch, F., Delagrange, P., Canet, E., Boutin, J.A. Biochem. Pharmacol. (2001) [Pubmed]
 
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