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Nqo2  -  NAD(P)H dehydrogenase, quinone 2

Mus musculus

Synonyms: NMO2, NRH:quinone oxidoreductase 2, Nmor2, Ox-2, Ox2, ...
 
 
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Disease relevance of Nqo2

 

High impact information on Nqo2

 

Biological context of Nqo2

 

Anatomical context of Nqo2

  • The CHO cells overexpressing NQO2 and mouse keratinocytes expressing or deficient in NQO2 were treated with varying concentrations of mitomycin C (MMC), CB1954, MMC analog BMY25067, EO9, menadione and BP-3,6-quinone, in the absence and presence of NRH [3].
 

Associations of Nqo2 with chemical compounds

  • The CHO cells overexpressing higher levels of mouse NQO2 showed significantly increased cytotoxicity to menadione, BP-3,6-quinone and to the anti-tumor drugs MMC and CB1954 when compared to CHO cells expressing endogenous NQO2 [3].
  • The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs [3].
 

Other interactions of Nqo2

  • The absence of BPQ-induced skin carcinogenicity in NQO1-/- mice may be related to the strain (C57BL/6) of mice used in the present study and/or due to poor BPQ absorption into the skin and/or due to detoxification of BPQ by cytosolic NRH:quinone oxidoreductase 2 (NQO2) [5].

References

  1. NQO1 and NQO2 Regulation of Humoral Immunity and Autoimmunity. Iskander, K., Li, J., Han, S., Zheng, B., Jaiswal, A.K. J. Biol. Chem. (2006) [Pubmed]
  2. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. Iskander, K., Paquet, M., Brayton, C., Jaiswal, A.K. Cancer Res. (2004) [Pubmed]
  3. NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Celli, C.M., Tran, N., Knox, R., Jaiswal, A.K. Biochem. Pharmacol. (2006) [Pubmed]
  4. Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3. Mailliet, F., Ferry, G., Vella, F., Thiam, K., Delagrange, P., Boutin, J.A. FEBS Lett. (2004) [Pubmed]
  5. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Joseph, P., Long, D.J., Klein-Szanto, A.J., Jaiswal, A.K. Biochem. Pharmacol. (2000) [Pubmed]
 
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