The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Nqo2  -  NAD(P)H dehydrogenase, quinone 2

Mus musculus

Synonyms: NMO2, NRH:quinone oxidoreductase 2, Nmor2, Ox-2, Ox2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nqo2


High impact information on Nqo2


Biological context of Nqo2


Anatomical context of Nqo2

  • The CHO cells overexpressing NQO2 and mouse keratinocytes expressing or deficient in NQO2 were treated with varying concentrations of mitomycin C (MMC), CB1954, MMC analog BMY25067, EO9, menadione and BP-3,6-quinone, in the absence and presence of NRH [3].

Associations of Nqo2 with chemical compounds

  • The CHO cells overexpressing higher levels of mouse NQO2 showed significantly increased cytotoxicity to menadione, BP-3,6-quinone and to the anti-tumor drugs MMC and CB1954 when compared to CHO cells expressing endogenous NQO2 [3].
  • The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs [3].

Other interactions of Nqo2

  • The absence of BPQ-induced skin carcinogenicity in NQO1-/- mice may be related to the strain (C57BL/6) of mice used in the present study and/or due to poor BPQ absorption into the skin and/or due to detoxification of BPQ by cytosolic NRH:quinone oxidoreductase 2 (NQO2) [5].


  1. NQO1 and NQO2 Regulation of Humoral Immunity and Autoimmunity. Iskander, K., Li, J., Han, S., Zheng, B., Jaiswal, A.K. J. Biol. Chem. (2006) [Pubmed]
  2. Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis. Iskander, K., Paquet, M., Brayton, C., Jaiswal, A.K. Cancer Res. (2004) [Pubmed]
  3. NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Celli, C.M., Tran, N., Knox, R., Jaiswal, A.K. Biochem. Pharmacol. (2006) [Pubmed]
  4. Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3. Mailliet, F., Ferry, G., Vella, F., Thiam, K., Delagrange, P., Boutin, J.A. FEBS Lett. (2004) [Pubmed]
  5. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Joseph, P., Long, D.J., Klein-Szanto, A.J., Jaiswal, A.K. Biochem. Pharmacol. (2000) [Pubmed]
WikiGenes - Universities