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Gene Review:

CeHV15gEBNA-2 - EBNA-2

Macacine herpesvirus 4

Peng, R. et al., Grabusic, K. et al.

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Disease relevance of CeHV15gEBNA-2

The Epstein-Barr virus (EBV) EBNA-LP and EBNA2 proteins are the first to be synthesized during establishment of latent infection in B lymphocytes [1].

High impact information on CeHV15gEBNA-2

EBNA2 is a key transcriptional regulator of both viral and cellular gene expression and is essential for EBV-induced immortalization of B lymphocytes [1].
The phenotype of B cells and LCLs infected with the DeltaCR4-EBNA2 mutant virus indicated that the CR4 region of EBNA2 specifically contributes to the viability of the cells rather than affecting cell division rates [2].

References

Sequence and functional analysis of EBNA-LP and EBNA2 proteins from nonhuman primate lymphocryptoviruses. Peng, R., Gordadze, A.V., Fuentes Pananá, E.M., Wang, F., Zong, J., Hayward, G.S., Tan, J., Ling, P.D. J. Virol. (2000) [Pubmed]
The CR4 region of EBNA2 confers viability of Epstein-Barr virus-transformed B cells by CBF1-independent signalling. Grabusic, K., Maier, S., Hartmann, A., Mantik, A., Hammerschmidt, W., Kempkes, B. J. Gen. Virol. (2006) [Pubmed]

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